Hypoglycemic and High Dosage Effects of Bidens pilosa in Type-1 Diabetes Mellitus
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Date
2015-08
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Research Publishing
Abstract
Ethno-pharmaceutical products have received a lot of international attention in the scientific community
in the management of diabetes mellitus (DM). In this study we determined the anti-diabetic
and high dosage effects of Bidens pliosa in type 1 DM (T1DM). Methodology: Thirty rats were
divided into six groups and subgrouped into the extract and non extract treatment groups. The
extract treated group was subdivided into three groups which received 200 mg/kg, 400 mg/ kg
and 800 mg/kg dosage treatments respectively. The blood glucose levels were monitored using a
standard glucometer for one month, and biochemical analysis of the two liver function enzymes;
Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were carried out at the Institute
of Biomedical Research (IBR-KIU-WC) at the end of week IV. The study revealed that Bidens
pilosa maintained hypoglycemia for a period of two weeks and this status was lost in subsequent
weeks. T1DM rats treated with a dosage of 200 mg/kg showed a better recovery (355.25 - 164.5
mg/dl) of the glucose levels, followed by those that were being treated at 400 mg/kg. The AST and
ALT enzymes in blood varied with a mean ± SEM (33.72 ± 32.32 to −7.23 ± 12.61 IU and 22.98 ±
11.12 to 42 ± 38.2 IU, respectively) in both the glibencimide® and in the 800 mg/ kg treatment
groups in the study. High dosages of extract were associated (P = 0.049) with increased systemic
enzyme leakage. In conclusion, tissue degeneration caused by high levels of the extract was accompanied
by leakage of various enzymes (AST and ALT) into the blood, which could be a major
etiological factor for the development of secondary systemic pathologies, thus potentially worsening
the effects of an existing T1DM prognosis in human patients.
Description
John Nnamdi Ejekwumadu, Keneth Iceland Kasozi, Julia Pantoglou, Elvis Ngala Mbiydzenyuy, Nancy Bonareri Mitaki Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University Western Campus, Bushenyi, Uganda
Institute of Biomedical Research, Kampala International University Western Campus, Bushenyi, Uganda
Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus,
Bushenyi, Uganda
Keywords
Type 1 Diabetes Mellitus, Bidens pilosa, Diabetes, Ethno-Pharmaceutical Medicine in Uganda, Sub-Saharan Africa and Diabetes
Citation
How to cite this paper: Ajagun-Ogunleye, M.O., Tirwomwe, M., Mitaki, R.N., Ejekwumadu, J.N., Kasozi, K.I., Pantoglou, J., Mbiydzenyuy, E.N. and Mitaki, N.B. (2015) Hypoglycemic and High Dosage Effects of Bidens pilosa in Type-1 Diabetes Mellitus. Journal of Diabetes Mellitus, 5, 146-154. http://dx.doi.org/10.4236/jdm.2015.53018