Effect of a Mixture of Allium Cepa and Camellia Sinensis Extracts On Hyperlipidemic Male Wistar Rats
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Date
2017-11
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Publisher
Kampala International University, College of Applied Sciences
Abstract
The burden of hyperlipidemia is on the rise globally especially in many low income
countries like Uganda. Management of this metabolic disorder mainly involves dietary and
behavioral therapies, which are often met with poor results as they require time and
discipline from the patients. The chemotherapeutic options available are expensive, are
associated with many side effects and are not readily available to the average citizen. Thus,
an alternative effective remedy which is readily available and cheap is needed to combat the
problem of hyperlipidemia. This study sought to establish the combination of Allium cepa
and Camellia sinensis extracts with the highest antioxidant activity and evaluated the effect
of this mixture on the plasma lipid profile of the male wistar rats. It also assessed the toxic
effect of the mixture on the liver. The mixture of Allium cepa and Camellia sinensis at a
ratio of 3:7 had the highest antioxidant activity. It reduced body weight, reduced total
cholesterol, increased HDL and had no toxicity to the liver. It has thus been recommended
as a potential therapy for hyperlipidemia and its associated complication of liver toxicity. A
further study on the kinetics of the interaction of the antioxidants in the mixture has also
been recommended.
Description
A Dissertation Submitted to Kampala International University in Fulfillment of the Requirements for the Award of a Master’s Degree in Biochemistry
Keywords
Allium Cepa Extracts, Camellia Sinensis Extracts, Hyperlipidemic Male Wistar Rats