New Combination Methods of Detecting Drug Interaction and Monitoring Adverse Drug Reactions in "Close System Pharmacy".
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Date
2012-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kampala International University, School of Health Sciences.
Abstract
Pharmacovigilance is an essential phenomenon in the rational use of medicine, providing
information about ADR in general population. Tracking ADR in" close system pharmacy" which
has relied on use of yellow forms and feed back following exposure to drugs has been
inadequate. Alternative methods are therefore required.
In the present study, the use of a combination of two methods to determine possible interactions
prior to dispensing and adverse drug reactions following exposure to drugs was evaluated using
computer software and mobile phone technology.
Two hundred and thirty randomly selected prescriptions were evaluated and carried a total of 660
drugs. Antibiotics (34%), analgesics(23%), vitamin(l4.1 %) and antimalarials(? .I%) drugs were
most commonly prescribed to the patients enrolled in the study. Prescriptions of atleast 3 drugs
occurred in 152 patients with 32.6% ofthese patients exposed to exactly 3 drugs.
Using Medscape software for drug interaction, 99(43%) prescriptions of 230 had interactions
detected; (minor in 33, significant in 57 and a mix of both in 9). All patients enrolled carried at
least one mobile phone with a service provider from four available in the region. Mean Effective
contact ratio was 0.92 for drug reaction monitoring in the patients for fourteen days. Of the 230
patients monitored drug reaction was reported in 48%. Within the period of study, no yellow
form was recorded in the hospital. No A b/2. ""o.-.s d<~-~ fTofn the r.epoy Jed. reacA lms ยท
The finding from_ this suggests that use of soft ware service monitor for possible drug
interactions and mobile phones presents a better compliment to use of yellow forms for tracking
ADR monitoring in hospital setting.
Description
A dissertation submitted to School of Pharmacy Kampala
International University-Western Campus in Partial Fulfillment of
the Requirements of the Award of Bachelor of Pharmacy.
Keywords
Drugs, New Combination, Drug Reactions, Close System Pharmacy