KIU Institutional Repository

Research and publications for Kampala International University Community

 

Recent Submissions

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An Insight of Interleukin -6 and Fibrinogen: In Regulating the Immune System
(Journal of Biomedical Sciences, 2022) Emmanuel Ifeanyi Obeagu; Emmanuel Muhimbura; Byamungu Pahari; Kagenderezo; Sarah Nakyeyune; Getrude Uzoma Obeagu
The role of the liver as a critical part of the immune system involved in both innate and adaptive immunity. As a major source of acute phase proteins, including components of the complement system. Hepatocytes are an important part of innate immunity and play an important role in controlling inflammatory responses throughout the body. Acute-phase protein production in hepatocytes is controlled by various cytokines released during the inflammatory process, with IL-6 and IL-1 type cytokines acting as key regulators, cascading and synergistic regulation or it functions as a cascade network with inhibition. Effects on acute-phase protein expression. The pro inflammatory cytokine interleukin-6 is an endogenous biochemical active during B cell maturation and inflammatory processes. Interleukin-6 plays an important role in regulating acute-phase protein synthesis in human hepatocytes
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Anemia, iron, and HIV: decoding the interconnected pathways A review
(Medicine, 2024) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Nkiruka Rose Ukibe; Samson Adewale Oyebadejo
This review delves into the intricate relationship between anemia, iron metabolism, and human immunodeficiency virus (HIV), aiming to unravel the interconnected pathways that contribute to the complex interplay between these 3 entities. A systematic exploration of relevant literature was conducted, encompassing studies examining the association between anemia, iron status, and HIV infection. Both clinical and preclinical investigations were analyzed to elucidate the underlying mechanisms linking these components. Chronic inflammation, a hallmark of HIV infection, disrupts iron homeostasis, impacting erythropoiesis and contributing to anemia. Direct viral effects on bone marrow function further compound red blood cell deficiencies. Antiretroviral therapy, while essential for managing HIV, introduces potential complications, including medication-induced anemia. Dysregulation of iron levels in different tissues adds complexity to the intricate network of interactions. Effective management of anemia in HIV necessitates a multifaceted approach. Optimization of antiretroviral therapy, treatment of opportunistic infections, and targeted nutritional interventions, including iron supplementation, are integral components. However, challenges persist in understanding the specific molecular mechanisms governing these interconnected pathways. Decoding the interconnected pathways of anemia, iron metabolism, and HIV is imperative for enhancing the holistic care of individuals with HIV/AIDS. A nuanced understanding of these relationships will inform the development of more precise interventions, optimizing the management of anemia in this population. Future research endeavors should focus on elucidating the intricate molecular mechanisms, paving the way for innovative therapeutic strategies in the context of HIV-associated anemia.
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Anemia as a Prognostic Marker for Disease Progression in HIV Infection
(IAA Journal of Biological Sciences, 2023) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Esther Ugo Alum; Okechukwu Paul-Chima Ugwu
Anemia, a prevalent hematologic manifestation in individuals living with Human Immunodeficiency Virus (HIV) infection, has garnered considerable attention as a prognostic indicator for disease progression and adverse clinical outcomes. This abstract presents a comprehensive review elucidating the intricate relationship between anemia and the progression of HIV infection, incorporating epidemiological trends, underlying pathophysiological mechanisms, clinical implications, and prognostic significance. Despite advances in antiretroviral therapy (ART), anemia remains a frequent complication in HIV infected individuals, posing substantial challenges to patient management. This paper aims to provide a nuanced understanding of anemia's role as a prognostic marker, surpassing its conventional characterization as a hematologic abnormality in the context of HIV infection. Anemia's role as a predictive marker for adverse clinical outcomes in HIV patients is explored, encompassing increased mortality rates, heightened risk of opportunistic infections, accelerated disease progression, and compromised quality of life. The review delves into its prognostic significance, shaping therapeutic decisions and prognostic assessments. This paper encapsulates the criticality of anemia as a prognostic marker for disease progression in HIV infection. Understanding its epidemiology, pathophysiological mechanisms, clinical implications, and prognostic significance is pivotal for informed clinical decision-making, prognostic assessments, and optimizing care paradigms in HIV management.
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Advancements in Myeloid Leukemia Treatment:A Comprehensive Update.
(Journal of Biological Sciences, 2023) Hauwa Ali Buhari; Salisu, Muhammad; Obeagu Emmanuel Ifeanyi
This comprehensive update explores the recent advancements in the treatment landscape of myeloid leukemia. Myeloid leukemia, a heterogeneous group of hematological malignancies, poses significant challenges in clinical management. This review highlights the latest therapeutic approaches, including targeted therapies, immunotherapies, and emerging treatment modalities. It discusses the impact of precision medicine, novel drug developments, and the evolving role of immunotherapy in managing myeloid leukemia. Furthermore, the abstract outlines current research trends, challenges, and future prospects, aiming to provide a concise overview for healthcare professionals and researchers involved in leukemia management.
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Advancements in Immune Augmentation Strategies for HIV Patients
(IAA Journal of Biological Sciences, 2023) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Esther Ugo Alum; Okechukwu Paul-Chima Ugwu
The management of HIV has witnessed a transformative shift owing to innovative approaches aimed at bolstering immune status in affected individuals. The landscape of HIV treatment has undergone a profound transformation with the emergence of innovative approaches dedicated to fortifying the immune status of individuals living with the virus. This abstract provides a succinct yet comprehensive overview of groundbreaking strategies aimed at augmenting immune health in HIV patients. Encompassing advancements in immunotherapy, personalized medicine, lifestyle modifications, and telemedicine, this overview highlights the promising trajectory and potential impact of these novel interventions in the realm of HIV care. By exploring the multifaceted dimensions of immune enhancement strategies, this abstract sets the stage for a deeper understanding of these innovative approaches and their pivotal role in shaping the future of HIV management