College of Education, Open & Distance Learning
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Browsing College of Education, Open & Distance Learning by Author "Emmanuel Ifeanyi Obeagu"
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- ItemAdvances in Laboratory Diagnosis and Clinical Management ofGilbert Disease :A Comprehensive Review(IAA Journal of Scientific Research, 2024-06-01) Nkiruka R Ukibe; Chioma Theresa Onwe; C.E. Onah Ezinne G Ukibe; Blessing C.Ukibe; Victory Ezennia Ukibe; Emmanuel Ifeanyi ObeaguGilbert’s syndrome (GS) is an extensively mild condition characterized by periods of elevated levels of bilirubin in the blood. The bilirubin is an orange yellowish tinted molecule which is produced when red blood cells are broken down and this substance is eliminated from the body only after it undergoes bio-transformation in the liver which converts unconjugated bilirubin to conjugated bilirubin. When the level of unconjugated bilirubin increases beyond a determined point, the bilirubin pigment starts to discolour the cornea of the eyes (making them to appear light yellow) and with higher levels the skin may also turn to yellow (jaundice). Gilbert’s syndrome also known as constitutional hepatic dysfunction and familial non haemolytic jaundice. People with Gilbert’s syndrome have an inherited abnormality that causes reduced production of an enzyme involved in processing of bilirubin. A