Browsing by Author "C.E. Onah1 Ezinne G. Ukibe"

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    Advances in Laboratory Diagnosis and Clinical Management of Gilbert Disease: A Comprehensive Review
    (Journal of Scientific Research, 2024) Nkiruka R Ukibe; Chioma Theresa Onwe; C.E. Onah1 Ezinne G. Ukibe; Blessing C. Ukibe; Victory Ezennia Ukibe; Emmanuel Ifeanyi Obeagu
    Gilbert’s syndrome (GS) is an extensively mild condition characterized by periods of elevated levels of bilirubin in the blood. The bilirubin is an orange yellowish tinted molecule which is produced when red blood cells are broken down and this substance is eliminated from the body only after it undergoes bio-transformation in the liver which converts unconjugated bilirubin to conjugated bilirubin. When the level of unconjugated bilirubin increases beyond a determined point, the bilirubin pigment starts to dis colour the cornea of the eyes (making them to appear light yellow) and with higher levels the skin may also turn to yellow (jaundice). Gilbert’s syndrome also known as constitutional hepatic dysfunction and familial non hemolytic jaundice. People with Gilbert’s syndrome have an inherited abnormality that causes reduced production of an enzyme involved in processing of bilirubin. A presumptive diagnosis of Gilbert’s syndrome is made when unconjugated hyper bilirubin anemia is noted on several occasions