Browsing by Author "Kalange, Muhamudu"

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    Blood Group Distribution in a Study Population and their Associated Rhesus Factor (Uganda)
    (Scholars Academic and Scientific Publisher, 2015) Mukinda, Frank Kamya; Lule, Herman; Kalange, Muhamudu; Echoru, Isaac; Ninsiima, Herbert Izo; Kasozi, Keneth Iceland
    Whole blood transfusions have continuously been done in medical hospitals as the major line of emergency recovery on the African continent as a result of limited infrastructure despite of the fact that the general blood group status is poorly understood. The aim of the study was to determine the prevalent blood groups and their associated rhesus factor. This was a cross sectional study conducted for a period of two months at Kampala International University Teaching Hospital involving a total of 47 undergraduate students, blood was picked by pricking the index finger and placed on a white tile from which the antigens were added to it. The study revealed that majority (53.2%) of the population had blood group O with the greatest prevalence being in the male population and blood group B was the second prevalent blood group in this study. This would probably be due to the establishment of endemic stability with malaria infections in the community. This would be due to genetic selection thus favoring the proliferation of the B and O blood groups as they appear to offer a mutuality protective advantage against plasmodium parasites. The major associated Rhesus factor were of O+ (53.2%) and B+ (21.3%) which showed that there was a significant downward shift in the levels of the Rhesus antigen. Blood group O was the most prevalent probably due to its evolutionary advantage in the region. Phenotypic expression need to be investigated further for the development of a strong hematological team in various rural communities.
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    Community Education Challenges in Young Adults of South Western Uganda
    (Scientific Research Publishing Inc., 2015-02) Kasozi, Keneth Iceland; Echoru, Isaac; Mbiydzenyuy, Elvis Ngala; Kimwise, Aaron; Nansunga, Miriam; Semuyaba, Ibrahim; Kalange, Muhamudu; Ninsiima, Herbert Izo; Muggaga, Kintu; Emorut, Simon Peter
    The aim of this study was to identify the major challenges to community education and any health problem in Bushenyi district of South Western Uganda. Data collection was done through questionnaire and participants were randomly selected. This was a cross-sectional study carried out for a period of three months in 2012. A questionnaire was used to collect data and using onsite observations the responses were validated. A total of 260 participants from 65 homesteads were included in the study from 52 households. 144 were females and 116 males, of which 52.4% of the children were female and the rest male. The mean ± SEM age of females and males was 36 ± 8.6 and 29 ± 8.6 years respectively. In all the homesteads, 71% were headed by an adult male and only 29% were found to be headed by an adult female while none was headed by children. Inferential analysis showed (P = 0.02) that there are more females than male in the homesteads. Majority of the homesteads are being taken care of by women instead of men probably as a result of the high mortalities due to HIV/AIDS in the past decade and above all the movement of most men to urban centers in search of better sources of employment to support their families. Among school going age participant’s i.e. children and adolescents, only 59.6% were found to be attending school. There was no statistical significance (P = 0.16) between school attendance and age. Family responsibilities such as cooking for younger siblings by female participants, obligations on open market days are thought to be secondary limiting factors for community development and livelihood among young persons; thus a follow up study would be conducted to assess their associations in this community as this would raise major child abuse concerns which would need to be reported to the legal authorities for follow up.
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    Effects of selected artemisinin-based antimalarial combination therapies (acts) on indomethacin induced gastric ulcers in wistar rats
    (Kampala International University, School of Health Sciences, 2017-05) Kalange, Muhamudu
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    Epidemiology of Coccidian Parasites in HIV Patients of Northern Uganda
    (SCIENCEDOMAIN international, 2015-04) Echoru, Isaac; Herman, Lule; Micheni, Lisa; Ajagun-Ogunleye, Mulkah O.; Kalange, Muhamudu; Kasozi, Keneth Iceland
    Aim: The epidemiology of coccidian parasites in HIV patients of sub-sahara Africa is poorly understood. This study aimed at determining the epidemiology of coccidian parasites and their associated risk factors. This was a cross sectional study carried out in Arua district in West Nile region of Northern Uganda for a period of five months. Materials and Methods: Participants in the study included HIV positive patients presenting with diarrhea. A total of 111 patients were included and classified into children, middle aged and adults. A structured questionnaire was administered, stool samples were obtained using sterile stool containers and laboratory analysis carried out using modified Ziehl-Neelsen technique (ZN). Ethical clearance was acquired and the consent of the patients was sought. Results and Discussion: Prevalence of Coccidian parasites among HIV patients was found to be 5.4% and Cryptosporidium parvum showed more prevalence than Isospora belli and Cyclospora cayatenensis i.e. (3.6%), (1.8%) and (0.0%) respectively. Most Cryptosporidium parvum infections occurred in children (13.6%) compared to adults (3.3%); with a significant relationship of (p = 0.02). The infection was higher in females (7.1%) than males (2.4%) (p = 0.19). The major risk factors associated with the disease were mainly consumption of contaminated and un-boiled water from taps and boreholes. HIV patients who took co-trimoxazole and drunk boiled water were shown to have a low prevalence of coccidian parasites of 1.9% and 2.6% respectively (p<0.05). This is because cotrimoxazole is a prophylactic drug for opportunistic infections and proper boiling of drinking water kills coccidian parasites. Conclusion and Recommendations: The study highlighted the importance and need to screen for coccidian parasites and emphasis on regular taking of prophylactic treatment as a way of controlling opportunistic infections in HIV patients. Future prevalence studies of Coccidia amongst healthy, HIV sero-negative children and adults of similar age groups in similar settings are recommended to ratify the relationship.