Browsing by Author "Nicholas Kusiima"

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    Combating the Spread of COVID-19, the Challenges Faced and Way forward for the International Community: A Review
    (Open Access Library Journal, 2020) Theophilus Pius; Saphurah Nabaasa; Nicholas Kusiima; Nicholas Kusiima; Ssebuufu Robinson
    Coronavirus disease (COVID-19) caused by SARS-COV2 has been a great disaster globally; affecting human lives, world economy, social activities, and above all lack of trust among countries of the world. The dreaded disease has about more than 3,713,796 confirmed cases, 263,288 deaths, and 1,341,059 recovered persons in May 2020. The main purpose of this article is to review measures put in place to combat COVID-19, challenges faced, and way forward for the international community. The study reviewed relevant articles on COVID-19 and measures put in place for combating the spread of COVID-19. The inconsistency in the prevention and control of COVID-19 and unwillingness by the people especially, in developing countries such as Africa has hampered the effective implementation of universal control measures to combat the disease. Also, the lack of a universal approved treatment and lack of trust amongst regions of the world to combat the disease have left many countries to struggle for themselves. The earlier report that the COVID-19 is not airborne and the recent report that is airborne has done more harm than good in terms of preventive measures. Another challenge observed is the lack of a complete understanding of the coronavirus by the scientific community. The association of the COVID-19 with 5G network was another distraction and confusion to the international community in combating the disease as people who were supposed to observe control and preventive measures, found themselves protesting and vandalizing the 5G tower thereby exposing themselves at risk of been infected with coronavirus. There is a need for a consensus on preventive measures and treatment through evidence- based research that will be effective in combating COVID-19 globally. During this global crisis with COVID-19, the international community must decentralize the testing centers to reach out to the rural areas instead of waiting for case reports from such areas. Social network owners should find a way of filtering and controlling information shared during outbreaks and Pandemics in the future.
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    Galinsoga parviflora restored associated motor coordination through increased linear distribution of Purkinje Cells in mercury chloride-induced toxicity of mice’s cerebellum
    (African Journal of Cellular Pathology, 2022-06-02) John Tabakwot Ayuba; Akeem Ayodeji Okesina; Ibe Michael Usman; Ichael Kunle Ajenikoko; Theophilus Pius; Nicholas Kusiima; Saidi Odoma; Mario Fernandez Edgar
    African Journal of Cellular Pathology Mercury (Hg) is a poisonous substance associated with diseases, such as ataxia and Joubert syndrome. Therefore, it is important to find a way to disrupt the process of Hg poisoning in the cerebellum, by exploring the medicinal value of local herb such as Galinsoga parviflora (GP). This study examined the effects of aqueous leaf extract of GP in HgCl2- induced cerebellar toxicity in adult male mice. Twenty-five adult male mice of an average weight of 25 g were randomly divided into 5 groups (n=5). Animals in Group I received oral administration of 2 ml/kg distilled water for 6 weeks, Group II received 2.3 mg/kg of HgCl2 for 3 weeks, Group III received 2.3 mg/kg of HgCl2 for the first 3 weeks followed by oral administration of 800mg/kg of GP extract for the next 3 weeks, Group IV received 800mg/kg of GP extract for the first 3 weeks followed by 2.3 mg/kg of HgCl2 for the next three weeks, and Group V received 2.3 mg/kg of HgCl2 and 800 mg/kg of GP extract concurrently for three weeks. The test animals were subjected to beam walking tests during the experiment period, followed by euthanasia, perfusion fixation, and tissue sample collection for histological and histochemical analysis. Treatment with the extract of GP showed varying degrees of regeneration in the cerebellar Purkinje cells and myelin sheath of mice in HgCl2 induced toxicity, with corresponding improvements in balance and posture. Cerebellar HgCl2 exposure in the present study was neurotoxic; however, treatment with GP was of therapeutic value.
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    Galinsoga parviflora restored associated motor coordination through increased linear distribution of Purkinje Cells in mercury chloride-induced toxicity of mice’s cerebellum
    (African Journal of Cellular Pathology, 2022) John Tabakwot Ayuba; Akeem Ayodeji Okesina; Ibe Michael Usman; Michael Kunle Ajenikoko; Theophilus Pius; Nicholas Kusiima; Saidi Odoma; Mario Fernandez Edga
    Mercury (Hg) is a poisonous substance associated with diseases, such as ataxia and Joubert syndrome. Therefore, it is important to find a way to disrupt the process of Hg poisoning in the cerebellum, by exploring the medicinal value of local herb such as Galinsoga parviflora (GP). This study examined the effects of aqueous leaf extract of GP in HgCl2-induced cerebellar toxicity in adult male mice. Twenty-five adult male mice of an average weight of 25 g were randomly divided into 5 groups (n=5). Animals in Group I received oral administration of 2 ml/kg distilled water for 6 weeks, Group II received 2.3 mg/kg of HgCl2 for 3 weeks, Group III received 2.3 mg/kg of HgCl2 for the first 3 weeks followed by oral administration of 800mg/kg of GP extract for the next 3 weeks, Group IV received 800mg/kg of GP extract for the first 3 weeks followed by 2.3 mg/kg of HgCl2 for the next three weeks, and Group V received 2.3 mg/kg of HgCl2 and 800 mg/kg of GP extract concurrently for three weeks. The test animals were subjected to beam walking tests during the experiment period, followed by euthanasia, perfusion fixation, and tissue sample collection for histological and histochemical analysis. Treatment with the extract of GP showed varying degrees of regeneration in the cerebellar Purkinje cells and myelin sheath of mice in HgCl2 induced toxicity, with corresponding improvements in balance and posture. Cerebellar HgCl2 exposure in the present study was neurotoxic; however, treatment with GP was of therapeutic value..