Browsing by Author "Obeagu, Getrude Uzoma"

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    The role of minimally invasive surgery in gallbladder carcinoma
    (Obeagu and Obeagu, 2023) Obeagu, Emmanuel Ifeanyi; Obeagu, Getrude Uzoma
    Gallbladder carcinoma is a malignant tumor that originates from the cells lining the gallbladder. It is a relatively rare form of cancer but is associated with a poor prognosis due to its aggressive nature and late-stage diagnosis. The incidence of gallbladder carcinoma varies geographically. Minimally invasive surgery, also known as minimally invasive techniques or laparoscopic surgery, is a modern surgical approach that aims to achieve therapeutic goals while minimizing surgical trauma and invasiveness. It involves utilizing specialized instruments and advanced technologies to perform surgical procedures through small incisions or natural body openings.
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    Understanding apoptosis in sickle cell anemia patients Mechanisms and implications
    (Wolters Kluwer Health, Inc., 2024) Obeagu, Emmanuel Ifeanyi; Nwanganga I, huoma Ubosi,; Obeagu, Getrude Uzoma; Egba, Simeon Ikechukwu; Bluth, Martin H.
    Sickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much research has focused on the molecular and cellular mechanisms underlying the pathophysiology of SCA, recent attention has turned to the role of apoptosis, or programmed cell death, in the disease progression. This review aims to elucidate the intricate mechanisms of apoptosis in SCA patients and explore its implications in disease severity, complications, and potential therapeutic interventions. Different research search engines such as PubMed central, Scopus, Web of Science, Google Scholar, ResearchGate, Academia Edu, etc were utilized in writing this paper. Apoptosis, a highly regulated cellular process, plays a crucial role in maintaining homeostasis by eliminating damaged or dysfunctional cells. In SCA, the imbalance between pro-apoptotic and anti-apoptotic signals contributes to increased erythrocyte apoptosis, exacerbating anemia and vaso-occlusive crises. Various factors, including oxidative stress, inflammation, and altered cell signaling pathways, converge to modulate the apoptotic response in SCA. Furthermore, the interaction between apoptotic cells and the vascular endothelium contributes to endothelial dysfunction, promoting the pathogenesis of vasculopathy and organ damage seen in SCA patients. In conclusion, unraveling the complexities of apoptosis in SCA provides valuable insights into the disease pathophysiology and offers novel avenues for therapeutic interventions. Abbreviations: DAMPs = damage-associated molecular patterns, HbS = hemoglobin S, SCA = sickle cell anemia.
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    Update on mothers towards neonatal umbilical cord sepsis:
    (International Journal of Current Research in Medical Sciences, 2023) Obeagu, Emmanuel Ifeanyi; Obeagu, Getrude Uzoma; Musiimenta, Esther; Yakubu, Sunday Bot; Abdulwasiu, Oladele Hassan
    Neonatal umbilical sepsis continues to be a major health problem with up to 323 of every 1000 neonates seen in clinics presenting with clinical symptoms. The unhealed umbilical cord is a major entry point for local and invasive infections during the neonatal period and is rapidly colonised by bacteria from the environment. The reasons for the high incidence of neonatal sepsis in developing countries are high incidence of home deliveries, unhygienic cord cutting, application of unclean substances to the stump and covering the stump with unclean fabric.