Browsing by Author "Ondieki, Miruka Conrad"

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    Availability of Essential Medicines and Supplies during the Dual Pull-Push System of Drugs Acquisition in Kaliro District, Uganda
    (Pharmaceutical Care & Health Systems, 2015-03) Bruno, Okiror; Onchweri, Albert Nyanchoka; Ondieki, Miruka Conrad; Nyabayo, Maniga Josephat
    The Ugandan government has experimented with various supply chain models for delivery of essential drugs and supplies. In 2010, the dual pull-push system was adopted; however drug stock outs are still a common occurrence in health facilities. This study on availability of essential medicines during the dual Pull-Push system in Kaliro District was undertaken, to be used as an indirect or direct indicator of effectiveness of the dual pull-push system of drugs acquisition in the district. The study combined quantitative and qualitative methods; the study mainly based on; document review (stock cards, delivery notes,) and key informant interviews. Results showed that average stock-out duration of essential medicines and supplies was 23.89% (20.47 % for essential medicines and 27.32% for medical supplies). ACT Artemether/lumefantrine 20/120 mg tablets had the highest percentage stock-out followed by Cotrimoxazole 480mg tablets (51.6 and 32.4 %, respectively). Among the short falls of the system were; drug requisitions based on neither morbidity nor consumption methods of quantification, delays during distribution, supplying medicines with short shelf life, rare condition drugs or low usage drugs. In conclusion, the trend of essential medicines and supplies availability during the dual pull-push system seemed to be declining since its initiation in 2010. It is thus recommended that national medical stores involve stakeholders at all stages of medicines and supplies planning, especially the district health officers, who are the final consumers in the supply chain. The government can also adopt a revolving drug fund system, in the form of ‘Special Pharmacies and drug stores’ to enhance availability of essential drugs in public facilities and thus improve the quality of health care.
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    Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides
    (OMICS Publishing Group, 2015-02) Ondieki, Miruka Conrad; Nyaribari, Matunda Conradus; Ejekwumadu, Nnamdi John; Nyakang’o, Mokembo Justin
    The hepatitis B virus continues to infect many millions of people worldwide. There is a need to develop new vaccines against the virus. Using immunoinformatics approaches, we have predicted epitopes within the hepatitis B virus surface antigen that can be used to develop a new vaccine. The predicted epitopes were then used to construct a synthetic vaccine. The interaction between the synthetic vaccine construct and major histocompatibility complex was also predicted using bioinformatics tools.