Browsing by Author "Sarah Nakyeyune"

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    An Insight of Interleukin -6 and Fibrinogen: In Regulating the Immune System
    (Journal of Biomedical Sciences, 2022) Emmanuel Ifeanyi Obeagu; Emmanuel Muhimbura; Byamungu Pahari; Kagenderezo; Sarah Nakyeyune; Getrude Uzoma Obeagu
    The role of the liver as a critical part of the immune system involved in both innate and adaptive immunity. As a major source of acute phase proteins, including components of the complement system. Hepatocytes are an important part of innate immunity and play an important role in controlling inflammatory responses throughout the body. Acute-phase protein production in hepatocytes is controlled by various cytokines released during the inflammatory process, with IL-6 and IL-1 type cytokines acting as key regulators, cascading and synergistic regulation or it functions as a cascade network with inhibition. Effects on acute-phase protein expression. The pro inflammatory cytokine interleukin-6 is an endogenous biochemical active during B cell maturation and inflammatory processes. Interleukin-6 plays an important role in regulating acute-phase protein synthesis in human hepatocytes
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    An Insight of Interleukin -6 and Fibrinogen: In Regulating the Immune System
    (Journal of Biomedical Sciences, 2022) Emmanuel Ifeanyi Obeagu; Emmanuel Muhimbura; Byamungu Pahari Kagenderezo; Sarah Nakyeyune; Getrude Uzoma Obeagu
    The role of the liver as a critical part of the immune system involved in both innate and adaptive immunity. As a major source of acute phase proteins, including components of the complement system. Hepatocytes are an important part of innate immunity and play an important role in controlling inflammatory responses throughout the body. Acute-phase protein production in hepatocytes is controlled by various cytokines released during the inflammatory process, with IL-6 and IL-1 type cytokines acting as key regulators, cascading and synergistic regulation or it functions as a cascade network with inhibition. Effects on acute-phase protein expression. The pro inflammatory cytokine interleukin-6 is an endogenous biochemical active during B cell maturation and inflammatory processes. Interleukin-6 plays an important role in regulating acute-phase protein synthesis in human hepatocytes.
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    An Update on Interferon Gamma and C Reactive Proteins in Sickle Cell Anaemia Crisis
    (Journal of Biomedical Sciences, 2022) Emmanuel Ifeanyi Obeagu; Byamungu Pahari Kagenderezo; Onyekachi Splendid Uwakwe; Sarah Nakyeyune; Getrude Uzoma Obeagu
    Sickle cell disease has been described by many scholars as a chronic inflammatory disease which is linked to many factors such as endothelial destruction, increased synthesis of reactive oxygen specie, haemolysis, increased synthesis of pro inflammatory cytokines among others. Inflammatory process play a major function in the activation of acute painful vaso-occlusion crisis that forms the main reason for the hospitalization of patients with sickle cell anaemia. Inflammatory processes, are key components of several complications of the disease including autosplenectomy, acute chest syndrome, pulmonary hypertension, leg ulcer, nephropathy and stroke and also ultimately initiates painful vaso-occlusion episodes that characterize Sickle Cell Disease. This study titled “Update on Interferon Gamma and C Reactive Proteins in Sickle Cell Anaemia in Crises, aims at finding out the recent updates on interferon gamma; a pro-inflammatory cytokine that plays a central role in inflammation and auto-immunity, and CRP; an acute phase protein used as a marker of inflammation in sickle cell anaemia patients in crisis. A lot of search engines were consulted in the course of writing this review such as scopus, Pubmed Central, Web of Science, Semantics, Google Scholar, Researchgate, Academia Edu, etc. Previous studies have suggested that levels of pro-inflammatory cytokines vary between steady-state and crisis states in SCA patients, hypothesized to help monitor clinical progression of the disease. . Newer therapies that target pathways downstream of the sickle are considered better options. This knowledge may have implications for the development of new treatments for sickle cell disease.
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    COVID 19 Omicron: The Origin, Presentation, Diagnosis, Prevention and Control
    (Asian Journal of Research in Infectious Diseases, 2022) Abdulwasiu Oladele Hassan; Emmanuel Ifeanyi Obeagu; David Toluwani Ajayi; Adeyemo Abolaji Tolulope; Chinelo Chioma Madekwe; Chika Chizitelu Madekwe; Justina N. Ikpenwa; Sarah Nakyeyune
    Coronaviruses have become a global health threat over the past two decades as their geographical spread has accelerated. Coronavirus disease 2019, also known as COVID-19, is the severe acute respiratory syndrome coronavirus 2 The epidemic caused by (SARS-CoV-2). The first known case was confirmed in Wuhan, China in December 2019, where he has caused two pandemics in the past. Severe acute respiratory syndrome and Middle East respiratory syndrome are followed by the current COVID-19 outbreak in China. The virus originates from a zoonotic source and is spread by direct and contact transmission. Symptoms range from fever to cough, muscle aches to severe respiratory failure. Diagnosis is confirmed by reverse transcriptase-PCR. Treatment of COVID-19 consists primarily of supportive care and mechanical ventilation in critical cases. Prevention strategies, along with successful disease isolation and community containment, play an important role in reducing the spread of the virus among the public. A vaccine has been developed to clear the virus from its host, but it is not yet known whether the vaccine works against the virus's newest subspecies, the Omicron subspecies. This review summarizes the most recent research advances in structure, epidemiology, and etiology. We also focused on mutational patterns, an important feature of viral virology, and examined existing variants, especially its omicron variant. The clinical features of COVID-19, current treatments, and scientific advances to combat the epidemic novel coronavirus were discussed