Browsing by Author "Vulli, Venkata Rao"

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    Antitumor activity of methanolic extract of vernoniacinerealess by human cell lines
    (International Journal of Current Advanced Research, 2016-07) Vulli, Venkata Rao
    Vernoniacinerea (L.) Less a member of family compositae (Asteraceae), is an important medicinal plant has already been in used as antibacterial, Analgesic, antipyretic, antiinflammatory preparation. In this study an attempt of the plant has been made to evaluate the anticancer activity of the methanolic extract of the plant, as stated in many hypothesis. Themethanolic extract of leaves of VernoniacinereaL. Were screened for their anticancer activity by cell linestudies was carried out by two methods Tetrazolium salt assay and Tryphan blue dye exclusion method. In MTT Assay the total growth inhibition (TGI) of methanol extract was found to be >10 mg/ml on both cell lines (HEp 2 and HT29). The relative cell survival progressively decreased in dose dependant manner. In addition to that, Short term Cytotoxicity studies by Tryphan Blue exclusion method also confirmed the anticancer activity of vernoniacinerea L. (1mg/ml showed 77% of Cytotoxicity inhibition). Our studies point the possibility of developing Vernoniacinerea L. as a novel potential agent in the area of cancer chemotherapy. Further investigation has to be carried out in isolation and characterization of active constituents and the mechanism involving in antitumor and cytotoxic effect.
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    Appraisal of antimicrobial medicinal plants with potential therapeutic effect on diabetes and sickle cell trait
    (Asian Journal of Phytomedicine and Clinical Research, 2016) Vulli, Venkata Rao; Odaya, Kumar P.; Sivanageswararao; Mekala, K. Srinivasu
    Amidst unbearable side effects, and the expensive nature of imported drugs used in the management of sickle cell disease and diabetes, the search for attractive alternative with emphasis on availability and safety, will continue especially in resource poor countries. Again, it’s not clear why there is sustained upsurge in diabetic and sickle cell disease despite efforts to clamp them down. The database on useful medicinal plants for treatment of diabetes and sickle cell was therefore improved. Other potential drugs suggested. Medicinal herbs can act as broad spectrum agents serving as anti-microbial, anti-diabetic and against sickle cell disease.