Bachelor of Medicine and Bachelor of Surgery(MBchB)

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    Disaster Fallout: Impact of Natural Calamities on HIV Control
    (IAA Journal of Applied Sciences, 2024) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Edward Odogbu Odo; Matthew Chibunna Igwe; Okechukwu Paul-Chima Ugwu; Esther U. Alum; Puche Racheal Okwaja
    Natural calamities possess a profound and multifaceted impact on HIV control, posing significant challenges to the infrastructure and initiatives aimed at managing the HIV/AIDS epidemic. This review scrutinizes the intricate dynamics between natural disasters and HIV control efforts, elucidating the disruptions these calamities create within prevention, treatment, and care programs. The repercussions extend from compromised healthcare services, heightened vulnerability among affected populations, to the impeded execution of preventive measures. Understanding the interplay between disasters and HIV control is pivotal for devising adaptive strategies capable of sustaining effective interventions during and in the aftermath of catastrophic events. This review amalgamates insights from existing literature, delving into the complexities and proposing mitigation strategies to fortify HIV control in disaster-prone regions.
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    Dehydration Status of Children 3-24 Months with Rota-Virus Diarrhoea at Fort Portal Regional Referral Hospital
    (International Network Organization for Scientific Research, 2023) Goretty Laker; Jolly Nankunda; Bernis Maren Melvis; Martin Nduwimana; Joel Kimera; Dickso Kajoba; Richard Justine Odong; Isaac Edyedu; Emmanuel Ifeanyi Obeagu
    The study was done to determine the prevalence of rotavirus diarrhea among children 3 to 24 months old at Fort Portal Regional Referral hospital. This was a hospital based cross sectional, descriptive and analytical study design to determine the prevalence, dehydration status and factors associated with Rota-virus diarrhea in children 3- 24 months in Fort Portal Regional Referral hospital. The study was carried out at Fort Portal Regional Referral Hospital pediatric (ward, OPD, Nutrition unit). Among the study participants with Rotavirus diarrhoea, majority had some dehydration 28(66.7%) while only 4.8% had severe dehydration. Majority of the participants with rotavirus diarrhea had some dehydration.
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    Current Advances in the Diagnosis and Treatment of Sickle Cell Anaemia
    (Newport International Journal of Biological and Applied Sciences (NIJBAS), 2023) Hauwa Ali Buhari; Aisha Sa’ad Ahmad; Emmanuel Ifeanyi Obeagu
    Sickle cell anemia (SCA) presents a complex challenge globally due to its significant morbidity and mortality. Recent advancements in diagnostic tools and treatment modalities have revolutionized the management of this hereditary hemoglobin disorder. This paper aims to synthesize current breakthroughs in the diagnosis and treatment of sickle cell anemia. Diagnostic techniques including genetic testing, hemoglobin electrophoresis, and advanced imaging methodologies are explored, providing insights into their accuracy and clinical applicability. Moreover, novel therapeutic approaches such as gene editing, fetal hemoglobin induction, and targeted therapies are discussed for their potential in ameliorating SCA-related complications and improving patient outcomes. The paper also assesses the challenges and future prospects in the field, emphasizing the need for comprehensive strategies that encompass early detection, personalized interventions, and ongoing research efforts. Understanding these recent strides in both diagnostics and therapeutics is pivotal in enhancing the care and prognosis of individuals afflicted with sickle cell anemia.
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    Contaminants of Domestic Rural Spring Water Sources In Bushenyi-Ishaka Municipality, Western Uganda
    (Journal of Health and Environmental Research, 2020) Solomon Adomi Mbina; Galimaka Wilson; Ejike Daniel Eze; Theophilus Pius; Ssebuufu Robinson; Adam Moyosore Afodun; Iliya Ezekie
    developed and developing countries. In Uganda, most water-borne diseases are known to be the leading causes of serious health burden among the inhabitants. The study objectives were to characterize microscopic isolates using biochemical tests as well as identify the possible sources of contamination of spring water which is the commonest source of water used by rural inhabitants for domestic activities in Bushenyi-Ishaka Municipality, Bushenyi district, Western Uganda. Samples of spring water were collected from all accessible spring water sources in Bushenyi-Ishaka Municipality, Western Uganda. A total of 48 spring water samples were collected using 500 ml sterile glass bottles. The sources of contamination of the spring water samples were determined using a Sanitary Inspection Checklist which was designed using some standard response factors from a collection of standard reference checklists for drinking water quality assessment. Distribution of isolates and indicator pathogens of fecal contamination recovered from positive samples shows 77.8% from Nyakabirizi, 75% from Ishaka and 52.63% from Central divisions. Among the isolates, Pseudomonas spp and Shigella spp appeared more frequent with overall percentage of (52.63%) and (45.83%) whereas, Klebsiella, Staphylococcus aureus and Escherichia coli were found in (31.25%), (12.5%) and (6.25%) respectively. Sanitary inspections showed that springs in Ishaka Division posed a much higher risk (66.7%) of bacterial contamination compared to what was observed in Central (58.3%) and Nyakabirizi (58.3%) Divisions. All the sampled water sources were contaminated hence they posed substantial risk to users in the communities. Regular water examination and quality control including microbial assessment of all water sources should be maintained in the three Divisions of the Bushenyi-Ishaka Municipality, Western Uganda.
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    Characterisation of HLA-DR antigen in patients type 1 diabetes mellitus in patient attending a tertairy hospital in Enugu, south-east Nigeria
    (2022) Ijeoma Leticia Okoroiwu; Emmanuel Ifeanyi Obeagu; Hilda González San Miguel; Sebastiana Arroyo Bote; Getrude Uzoma Obeagu
    Background: The association between HLA-DR antigen and diabetes mellitus was studied in know diabetic patient on medication at University of Nigeria Teaching Hospital Enugu. The study was done to characterize the HLA-DR antigen in patients with type 1 diabetes mellitus attending University of Nigeria Teaching Hospital, Enugu. Materials and methods: Ethical clearance was obtained from the Hospital Research Ethics Committee, while informed consent was obtained from each member of the studied group. Whole blood was collected from each subject using standard venipuncture into an EDTA anticoagulant bottle and fluoride tube. The fasting glucose level was determined by enzymatic oxidase-peroxidase method and glycated hemoglobin (HbAlc) spectrophotometric ally. The HLA-DR antigen alleles were studied using sequence specific primer polymerase chain reaction (SSP-PCR) techniques. Results: The mean results of glucose and HbAlc levels were normal and showed no significant difference when they were compared according to their alleles. The correlation using Kruskal-Wallis test and Dunn’s Multiple comparison test showed no significant difference in all the group; HbAlcvs HLA-DR antigens and glucose levels vs HLA-DR antigens P = 0.7325 and P = 0.6081. However, the alleles HLA- DRB4*01 (17.5%), DRB1* 03 (29.2%) and DRB1*15 (35%) showed higher frequencies in the group studied.