Effect of aloe vera ( L.Burn.F.) Crude extract on dolutegravir induced hyperglycaemia in wistar albino rats
| dc.contributor.author | Mugide Nuru | |
| dc.date.accessioned | 2026-08-20T06:43:16Z | |
| dc.date.available | 2026-08-20T06:43:16Z | |
| dc.date.issued | 2022-11 | |
| dc.description.abstract | This study aimed at evaluating the hypoglycaemic and toxicological effect of co-administration of DTG and aqueous extract of Aloe vera leaf in Wistar rats after 28 days. Aloe vera at three graded doses of 100, 300 and 400 mg/kg was concurrently administered with 2mg/kg of DTG once daily for 28 days to Wistar rats divided into six groups to evaluate its effect on their blood glucose levels and the biochemical, haematological and histopathological parameters after this period. Group I received only DTG, Group II received distilled water (control group), Group III, IV and V received 2mg/kg DTG and 100 mg/kg, 300 mg/kg and 400mg/kg Aloe vera respectively, while Group VI received only Aloe vera at 300mg/kg. Fasting blood glucose levels in mmol/L were taken on day 1 of intervention and weekly. A differential count to assess the haematological parameters was done. Serum markers assessed for liver included; Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline Phosphatase (ALP), Total protein (TP), and bilirubin. For the kidney, these included: blood Urea and serum creatinine, which were analyzed using calorimetric method while AST was analyzed using the method according to Hammed, 2011. Macroscopic and microscopic histopathological observations of the liver and kidney were also made. Results showed a hypoglycaemic effect of Aloe vera extract against DTG-induced hyperglycaemia when DTG-induced hyperglycaemic rats were treated with Aloe vera extract at daily dose levels of 300 and 400mg/kg for the 28 day study. All haematological parameters assessed were within the normal range except for the platelet count and mean platelet volume which were statistically significantly high in the animal groups that received Aloe vera leaf extract at 300 and 400 mg/kg. Mean values for ALT and AST for the animal group that received only DTG were statistically significantly high. Histopathological microscopic and macroscopic observations of the liver and kidney tissues were normal except for the animal group that was receiving DTG alone. We can conclude from the findings of this study that Aloe vera aqueous leaf extract at doses of 300 and 400 mg/kg is relatively safe and has hypoglycaemic effects against DTG-induced hyperglycaemia. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12493/14915 | |
| dc.language.iso | en | |
| dc.publisher | Kampala International University | |
| dc.title | Effect of aloe vera ( L.Burn.F.) Crude extract on dolutegravir induced hyperglycaemia in wistar albino rats | |
| dc.type | Thesis |