Datura metel Administration Distorts Medial Prefrontal Cortex Histology of Wistar Rats

dc.contributor.authorEtibor, Temitope Akhigbe
dc.contributor.authorAjibola, Musa Iyiola
dc.contributor.authorBuhari, Mohammad Olanrewaju
dc.contributor.authorSafiriyu, Abass Alao
dc.contributor.authorAkinola, Oluwole Busayo
dc.contributor.authorCaxton-Martins, Ezekiel A.
dc.date.accessioned2019-02-15T08:42:45Z
dc.date.available2019-02-15T08:42:45Z
dc.date.issued2015-07
dc.descriptionThe article is available full text, under Creative Commons and its Open Accessen_US
dc.description.abstractDatura metel is one of psychoactive substances of great ethno-pharmacological significance often abused because of its unrestricted availability, yet, little is known about its mechanisms of action. This work was therefore aimed at assessing the activity of ethanolic seed extract of D. metel on Nissl substances, astrocytes, axonal and neuronal integrity of the medial prefrontal cortex (mPFC) of Wistar rats. Eighteen Wistar rats averaging 175 g were used and randomly assigned to three groups: group A rats (n = 6) were administered extract of 100 mg/kg bw, group B rats (n = 6) received extract of 200 mg/kg bw, and group C-control (n = 6) took distilled water only for 14 days. The results revealed that D. metel is deleterious to the health of Wistar rats at a dose-dependent rate as observed in its actions on the medial prefrontal cortex at 100 mg/kg bw and 200 mg/kg bw. The histological study of the treated Wistar rats exhibited features of disoriented neuronal integrity such as, chromatolysis, reduced protein synthesis due to loss of Nissl substances and nuclei, neuronal loss as well as axonal injuries.en_US
dc.identifier.citationEtibor, T.A., Ajibola, M.I., Buhari, M.O., Safiriyu, A.A., Akinola, O.B. and Caxton-Martins, E.A. (2015) Datura metel Administration Distorts Medial Prefrontal Cortex Histology of Wistar Rats. World Journal of Neuroscience, 5, 282-291. http://dx.doi.org/10.4236/wjns.2015.54026en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12306/1586
dc.language.isoen_USen_US
dc.publisherScientific Research Publishingen_US
dc.relation.ispartofseriesWorld Journal of Neuroscience;5, 282-291
dc.subjectD. metelen_US
dc.subjectDatura stramoniumen_US
dc.subjectNissl Substanceen_US
dc.subjectPrefrontal Cortexen_US
dc.subjectChromatolysisen_US
dc.subjectDrug Abuseen_US
dc.titleDatura metel Administration Distorts Medial Prefrontal Cortex Histology of Wistar Ratsen_US
dc.typeArticleen_US
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