Selective effects of Datura Stramonium on the granular parallel fibres and purkinje cells of the cerebellum in Wistar rats

Simple item page
dc.contributor.authorSunday, Dare S.
dc.date.accessioned2019-02-14T13:12:52Z
dc.date.available2019-02-14T13:12:52Z
dc.date.issued2015
dc.descriptionDare S. Sunday Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Uganda.en_US
dc.description.abstractIntroduction: Datura stramonium (DS) is a tropical ubiquitous shrub which is often used to increase intoxication in some beverages and is also freely used as a hallucinogen. It is a depressant of the central nervous system, yet commonly smoked in like manner tobacco. The present study investigated changes induced by intoxication with DS on the purkinje cells and parallel fibres of the cerebellum in Wistar rats to further elucidate the effects of this drug on cerebellar structure. Materials and Methods: The study was conducted on both male and female Wistar rats (200-250 g). They were placed into three batches and four groups were derived from each batch, with eight animals per group. Ethanolic dried seed extract of DS was diluted in normal saline and administered intraperitoneally (I.P.) at a dose of 750mg/kg and given to the treatment groups: once in batch 1, twice in batch 2, twelve hourly and thrice in batch 3, eight hourly per day respectively for 4 weeks, while the control groups received an equivalent of normal saline. The rats were euthanized and sections of the cerebellum were histologically processed in all groups. Silver impregnation stain for degenerating axons and neurons was used to elucidate the actions of DS on purkinje cells and the parallel fibres of the cerebellum. Results: The result of IP administration of DS extract (750 mg/kg) given three times daily to the treated rats showed significant histological changes, which included atrophy of the parallel fibres but no significant changes in the purkinje cells of the cerebellum. Conclusions: Intoxication of DS seed as a result of excessive ingestion may have a selective degenerative effect on the parallel fibres of the granule cells of the cerebellum while the purkinje cells are spared; the implication being motor dysfunction.en_US
dc.identifier.issnISSN 2321-4287
dc.identifier.urihttp://hdl.handle.net/20.500.12306/1578
dc.language.isoenen_US
dc.publisherInternational Journal of Anatomy and Researchen_US
dc.subjectDatura stramoniumen_US
dc.subjectCerebellumen_US
dc.subjectPurkinje cellsen_US
dc.subjectParallel fibresen_US
dc.subjectAtrophyen_US
dc.subjectIntraperitonealen_US
dc.titleSelective effects of Datura Stramonium on the granular parallel fibres and purkinje cells of the cerebellum in Wistar ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
SELECTIVE EFFECTS OF DATURA STRAMONIUM ON THE.pdf
Size:
665.59 KB
Format:
Adobe Portable Document Format
Description:
Full text
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Human Anatomy