Assessment of the influence of ketoconazole on memory retrieval among adult wistar rats.

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dc.contributor.authorNyaribo, Cyprian Mose
dc.contributor.authorNyabayo, Josephat Maniga
dc.contributor.authorKerubo, Eunice Bogecho
dc.contributor.authorMarera, Dominic Oduor
dc.contributor.authorNyanchoka, Albert Onchwer
dc.contributor.authorMiruka, Conrald Ondieki
dc.date.accessioned2019-01-31T12:21:43Z
dc.date.available2019-01-31T12:21:43Z
dc.date.issued2016-02-22
dc.descriptionNyaribo Cyprian Mose, Nyabayo Josephat Maniga, Kerubo Eunice Bogecho Marera Dominic Oduor. Nyanchoka Albert Onchweri, Miruka Conrald Ondieki. School of Pharmacy and Health Sciences, United States International University – Africa, Nairobi, Kenya. Department of Microbiology, 3Department of Public Health, 5School of Pharmacy, 6Department of Biochemistry, Kampala International University, Western Campus, Ishaka, Bushenyi Uganda. 4Department of Human Anatomy, Maseno University, Maseno, Kenya.en_US
dc.description.abstractThe aim of the study is to investigate the influence of ketoconazole on memory retrieval among adult wister rats in relation to age and gender.Anxiety disorders are of concern and definite treatment is wanting in current medicine. Ketoconazole, a known glucocorticoid synthesis inhibitor was used in this study to reduce memory retrieval in rats which were subjected to a stressful and life threatening water maze training. We wanted to evaluate the time difference after ketoconazole treatment and possible hippocampus neuronal histological changes in the treated animals.At the end of this research study which lasted for eight (8) months, remarkable and appreciable results were found. On the average duration taken by the animals from the four different starting points of swimming trials, the differences between the values of escape latency before and after treatment were found not to be statistically significant (p>0.05). However, there was a possibility of handedness among animals as seen while turning right to the platform.We concluded that, the administration of ketoconazole did not exhibit significant inhibition of glucocorticoid synthesis since the memory retrieval and hippocampus neuronal morphology between the treated and untreated animals did not show significant statistical difference.en_US
dc.identifier.issn2306-5877
dc.identifier.urihttp://hdl.handle.net/20.500.12306/1540
dc.language.isoenen_US
dc.publisherAfrican Journal of Science and Researchen_US
dc.relation.ispartofseriesAfrican Journal of Science and Research,2016,(5)1:33-37;
dc.subjectGlucocorticoiden_US
dc.subjectKetoconazoleen_US
dc.subjectHippocampusen_US
dc.subjectLearningen_US
dc.subjectMemoryen_US
dc.subjectMazeen_US
dc.titleAssessment of the influence of ketoconazole on memory retrieval among adult wistar rats.en_US
dc.typeArticleen_US
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