Understanding apoptosis in sickle cell anemia patients Mechanisms and implications

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dc.contributor.authorObeagu, Emmanuel Ifeanyi
dc.contributor.authorNwanganga I, huoma Ubosi,
dc.contributor.authorObeagu, Getrude Uzoma
dc.contributor.authorEgba, Simeon Ikechukwu
dc.contributor.authorBluth, Martin H.
dc.date.accessioned2024-02-28T08:10:58Z
dc.date.available2024-02-28T08:10:58Z
dc.date.issued2024
dc.description.abstractSickle cell anemia (SCA) is a hereditary blood disorder characterized by the presence of abnormal hemoglobin, leading to the formation of sickle-shaped red blood cells. While much research has focused on the molecular and cellular mechanisms underlying the pathophysiology of SCA, recent attention has turned to the role of apoptosis, or programmed cell death, in the disease progression. This review aims to elucidate the intricate mechanisms of apoptosis in SCA patients and explore its implications in disease severity, complications, and potential therapeutic interventions. Different research search engines such as PubMed central, Scopus, Web of Science, Google Scholar, ResearchGate, Academia Edu, etc were utilized in writing this paper. Apoptosis, a highly regulated cellular process, plays a crucial role in maintaining homeostasis by eliminating damaged or dysfunctional cells. In SCA, the imbalance between pro-apoptotic and anti-apoptotic signals contributes to increased erythrocyte apoptosis, exacerbating anemia and vaso-occlusive crises. Various factors, including oxidative stress, inflammation, and altered cell signaling pathways, converge to modulate the apoptotic response in SCA. Furthermore, the interaction between apoptotic cells and the vascular endothelium contributes to endothelial dysfunction, promoting the pathogenesis of vasculopathy and organ damage seen in SCA patients. In conclusion, unraveling the complexities of apoptosis in SCA provides valuable insights into the disease pathophysiology and offers novel avenues for therapeutic interventions. Abbreviations: DAMPs = damage-associated molecular patterns, HbS = hemoglobin S, SCA = sickle cell anemia.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12306/14436
dc.language.isoenen_US
dc.publisherWolters Kluwer Health, Inc.en_US
dc.subjectApoptosisen_US
dc.subjectInflammationen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectSickle cell anemiaen_US
dc.subjectVaso-occlusive crisesen_US
dc.titleUnderstanding apoptosis in sickle cell anemia patients Mechanisms and implicationsen_US
dc.typeArticleen_US
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