Characterisation of HLA-DR antigen in patients type 1 diabetes mellitus in patient attending a tertairy hospital in Enugu, south-east Nigeria

Simple item page
dc.contributor.authorIjeoma Leticia Okoroiwu
dc.contributor.authorEmmanuel Ifeanyi Obeagu
dc.contributor.authorHilda González San Miguel
dc.contributor.authorSebastiana Arroyo Bote
dc.contributor.authorGetrude Uzoma Obeagu
dc.date.accessioned2024-10-29T13:01:34Z
dc.date.available2024-10-29T13:01:34Z
dc.date.issued2022
dc.description.abstractBackground: The association between HLA-DR antigen and diabetes mellitus was studied in know diabetic patient on medication at University of Nigeria Teaching Hospital Enugu. The study was done to characterize the HLA-DR antigen in patients with type 1 diabetes mellitus attending University of Nigeria Teaching Hospital, Enugu. Materials and methods: Ethical clearance was obtained from the Hospital Research Ethics Committee, while informed consent was obtained from each member of the studied group. Whole blood was collected from each subject using standard venipuncture into an EDTA anticoagulant bottle and fluoride tube. The fasting glucose level was determined by enzymatic oxidase-peroxidase method and glycated hemoglobin (HbAlc) spectrophotometric ally. The HLA-DR antigen alleles were studied using sequence specific primer polymerase chain reaction (SSP-PCR) techniques. Results: The mean results of glucose and HbAlc levels were normal and showed no significant difference when they were compared according to their alleles. The correlation using Kruskal-Wallis test and Dunn’s Multiple comparison test showed no significant difference in all the group; HbAlcvs HLA-DR antigens and glucose levels vs HLA-DR antigens P = 0.7325 and P = 0.6081. However, the alleles HLA- DRB4*01 (17.5%), DRB1* 03 (29.2%) and DRB1*15 (35%) showed higher frequencies in the group studied.
dc.description.sponsorshipKampala International University
dc.identifier.issn2255-0569
dc.identifier.urihttp://hdl.handle.net/20.500.12493/14554
dc.language.isoen
dc.titleCharacterisation of HLA-DR antigen in patients type 1 diabetes mellitus in patient attending a tertairy hospital in Enugu, south-east Nigeria
dc.title.alternativeCaracterización del antígeno HLA-DR en pacientes con diabetes mellitus de tipo1 que acuden a un hospital terciario de Enugu, en el sureste de Nigeria
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
characterisation-of-hla-dr-antigen-in-patients-type-1-diabetes-mellitus-in-patient-attending-a-tertairy-hospital-in-enugu-south-east-nigeria.pdf
Size:
283.69 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Bachelor of Medicine and Bachelor of Surgery(MBchB)