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Browsing Untitled by Author "Ahmad, Halilu"

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    Toxicity study of two herbs used by traditional healers of Rukararwe to treat herpes zoster in HIV Patients
    (Kampala International University.College of Health Science, 2016-06) Ahmad, Halilu
    Despite the fact that herbal medicines are used by 80% of the World's population (WHO, 2002) and are the main source of health care in the rural communities and the most preferred form of treatment of HIV-related symptoms (Orisatoki and Oguntibeju, 20 I 0), less than I 0% of herbal products in the world market are truly standardized to a known active and/or toxic components (Winston et al. , 2007). Study carried out in Western Uganda reported 32.8% of same-day use of herbal medicine and pharmaceutical drugs by HIV patients (Deanne et al., 2007). Herpes zoster as a common disease in HIV patients is treated by traditional healers of Rukararwe with herbal preparations without any knowledge on the possible interactions between the treatments and lack of documented evidences to support their claim. A im The aim or the stud) was to partic ipate in the compil ation of their traditional knowledge and make it available for future research, and also to avail the healers with the information on scientific literature. The study also evaluates the toxicity and interaction with ARVs of herbs used by traditional healers of Rukararwe in the treatment of Herpes zoster infection in HIVpositive patients. Materials and Methods Different concentrations of aq ueous and ethanol extracts of Warbugia ugandensis with or without food were fed on Drosophila 111elanogaster and acute toxicity, locomotion assay, longevity study of the flies was done in 3 replicates, together with preliminary phytochemical screening of different extracts. Sesbania sesban (1.33 ~tg/ l00ยต1) with or without ARVs (AZT, LVD and NVP) were fed on D. 111e/anogaster and copulation and mating assay, locomotion assay, longevity study of the fli es was done in 3 replicates. Results and Discussion Traditional healers mostly used oral formulation (80%), herbs for treating herpes zoster (40%). Steroids, Terpenoids and Glycosides were present in all extracts of W ugandensis. Extracts of W ugandensis were .not toxic after I hour of exposure. Ethanol extract of W ugandensis decreased ix negative geotaxis (P