Bachelor of Science in Microbiology

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https://testir.kiu.ac.ug/handle/20.500.12306/2814

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    Curtailing HIV/AIDS Spread: Impact of Religious Leaders
    (Newport International Journal of Research in Medical Sciences (NIJRMS), 2023) Esther Ugo Alum; Okechukwu P. C. Ugwu; Emmanuel Ifeanyi Obeagu; Michael Ben Okon
    The emergence of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) has posed a global threat to human health, economy, and longevity of life. Corollary, the search for treatment has been an extensive one and several breakthroughs have been made. However, prevention of HIV/AIDS is more economical than treatment and hence has been intensely advocated. Several measures have been championed by different groups. Worthy of note is the role of religious leaders in the dissemination of management and preventive measures for HIV/AIDS due to their exalted societal status and access to a large audience. Despite the gigantic strides made by religious leaders in curbing this menace, there are still some drawbacks. In this paper, we shall succinctly highlight the impacts made by religious leaders toward the annihilation of HIV/AIDS, the barriers to complete adherence to this advocacy, and steps to mitigate these setbacks.
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    Galinsoga parviflora restored associated motor coordination through increased linear distribution of Purkinje Cells in mercury chloride-induced toxicity of mice’s cerebellum
    (African Journal of Cellular Pathology, 2022-06-02) John Tabakwot Ayuba; Akeem Ayodeji Okesina; Ibe Michael Usman; Ichael Kunle Ajenikoko; Theophilus Pius; Nicholas Kusiima; Saidi Odoma; Mario Fernandez Edgar
    African Journal of Cellular Pathology Mercury (Hg) is a poisonous substance associated with diseases, such as ataxia and Joubert syndrome. Therefore, it is important to find a way to disrupt the process of Hg poisoning in the cerebellum, by exploring the medicinal value of local herb such as Galinsoga parviflora (GP). This study examined the effects of aqueous leaf extract of GP in HgCl2- induced cerebellar toxicity in adult male mice. Twenty-five adult male mice of an average weight of 25 g were randomly divided into 5 groups (n=5). Animals in Group I received oral administration of 2 ml/kg distilled water for 6 weeks, Group II received 2.3 mg/kg of HgCl2 for 3 weeks, Group III received 2.3 mg/kg of HgCl2 for the first 3 weeks followed by oral administration of 800mg/kg of GP extract for the next 3 weeks, Group IV received 800mg/kg of GP extract for the first 3 weeks followed by 2.3 mg/kg of HgCl2 for the next three weeks, and Group V received 2.3 mg/kg of HgCl2 and 800 mg/kg of GP extract concurrently for three weeks. The test animals were subjected to beam walking tests during the experiment period, followed by euthanasia, perfusion fixation, and tissue sample collection for histological and histochemical analysis. Treatment with the extract of GP showed varying degrees of regeneration in the cerebellar Purkinje cells and myelin sheath of mice in HgCl2 induced toxicity, with corresponding improvements in balance and posture. Cerebellar HgCl2 exposure in the present study was neurotoxic; however, treatment with GP was of therapeutic value.