Bachelor of Medical Laboratory Technology(BMLT)
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- ItemEclampsia: A Review on Risk Factors, Management and Outcome(Newport International Journal of Research in Medical Sciences (NIJRMS), 2023) Emmanuel Ifeanyi Obeagu; Stella Malot; Getrude Uzoma Obeagu; Carine ByukusengeEclampsia is when a person with preeclampsia develops seizures (convulsions) during pregnancy. Eclampsia remains a major cause of maternal mortality, particularly in teenage pregnancies. The prevalence of eclampsia globally is reported to be 0.3% but data from individual countries suggest that prevalence and mortality risk vary depending on region and socio-economic status. Family history of Hypertension, preeclampsia, low serum quantity of Calcium and Magnesium, are also risk factors.
- ItemDistribution of ABO, RhD Blood Group among Secondary School Students at Bishops Girls Secondary School Rushere Kiruhura Southwestern Uganda(International Digital Organization for Scientific Research, 2024) Benjamin Nuwareeba; Antony Atuhaire; Esau Mawejje; Emmanuel Ifeanyi ObeaguABO and Rhesus blood group antigens are inherited genetic markers in human blood. Haemoglobin is an efficient transporter of oxygen from the lungs to the tissues and carbon dioxide from tissues to the lungs for exhalation. The study was to determine the distribution of ABO and Rhesus blood groups among secondary school female students. The blood samples of 107 secondary school students at Bishops girls’ Secondary School Rushere kiruhura Southwestern Uganda between July to August, 2023 were collected and their haemoglobin genotypes were determined using HemoTypeSC™ rapid test kit and ABO and Rhesus blood groups were determined by a standard tube method. Results. The frequencies of ABO blood groups among the study population were 20 (18.5%), 24 (22.5%), 06 (5.4%) and 57 (53.6%) for blood group A, B, AB, and O respectively. Also, the distribution of Rhesus (D) positive and Rhesus (D) negative were reported as 98 (91.6%) and 9 (8.4%) each. There was no association between ABO, Rhesus (D) and Hb genotypes observed. Data revealed that Rhesus (D) positive students were statistically higher in number compared to the Rhesus (D) negative students (p=0.000). The sequence of ABO distribution among the rural population in southwestern Uganda is; O > A > B > AB. The frequency of Rhesus (D) negative is very low among secondary school students at Bishops’ Girls Secondary School Rushere Kiruhura Southwestern Uganda
- ItemDeciphering the Molecular Mechanisms Governing Autophagy: A Comprehensive Overview(IAA Journal of Scientific Research, 2024) Nkiruka R Ukib; Mmesoma Jessica Nwankwo; Onah C. E; Ezinne G. Ukibe; Blessing C. Ukibe; Victory Ezennia Ukibe; Emmanuel Ifeanyi ObeaguAutophagy, an evolutionarily conserved cellular process, intricately regulates the degradation and recycling of cellular components, ensuring cellular homeostasis. The molecular orchestration of autophagy involves a sophisticated network of signaling pathways and key molecular players. Key initiation steps involve nutrient-sensing pathways, including mTOR and AMPK, converging on the ULK1 complex, triggering autophagosome formation. Subsequent stages encompass the role of the PI3K complex, recruitment of ATGs, and autophagosome expansion, leading to cargo recognition and closure. The selectivity in autophagy is achieved through cargo-specific adaptors and receptors like p62/SQSTM1, NIX/BNIP3L, and NDP52, ensuring targeted degradation of damaged organelles, misfolded proteins, and pathogens. Upon fusion with lysosomes, autolysosomes are formed, culminating in the breakdown of engulfed cargo via lysosomal hydrolases. Autophagy's intricate interplay with cellular processes, including metabolism, immunity, and cell death pathways, underscores its multifaceted roles in physiological and pathological conditions. Dysregulated autophagy is implicated in neurodegenerative disorders, cancer, metabolic diseases, and infections, highlighting its clinical relevance. Understanding the molecular mechanisms of autophagy offers promising prospects for therapeutic interventions by targeting autophagic pathways. This overview provides insights into the molecular intricacies of autophagy, offering potential avenues for therapeutic modulation in various disease contexts.
- ItemCOVID 19 Omicron: The Origin, Presentation, Diagnosis, Prevention and Control(Asian Journal of Research in Infectious Diseases, 2022) Abdulwasiu Oladele Hassan; Emmanuel Ifeanyi Obeagu; David Toluwani Ajayi; Adeyemo Abolaji Tolulope; Chinelo Chioma Madekwe; Chika Chizitelu Madekwe; Justina N. Ikpenwa; Sarah NakyeyuneCoronaviruses have become a global health threat over the past two decades as their geographical spread has accelerated. Coronavirus disease 2019, also known as COVID-19, is the severe acute respiratory syndrome coronavirus 2 The epidemic caused by (SARS-CoV-2). The first known case was confirmed in Wuhan, China in December 2019, where he has caused two pandemics in the past. Severe acute respiratory syndrome and Middle East respiratory syndrome are followed by the current COVID-19 outbreak in China. The virus originates from a zoonotic source and is spread by direct and contact transmission. Symptoms range from fever to cough, muscle aches to severe respiratory failure. Diagnosis is confirmed by reverse transcriptase-PCR. Treatment of COVID-19 consists primarily of supportive care and mechanical ventilation in critical cases. Prevention strategies, along with successful disease isolation and community containment, play an important role in reducing the spread of the virus among the public. A vaccine has been developed to clear the virus from its host, but it is not yet known whether the vaccine works against the virus's newest subspecies, the Omicron subspecies. This review summarizes the most recent research advances in structure, epidemiology, and etiology. We also focused on mutational patterns, an important feature of viral virology, and examined existing variants, especially its omicron variant. The clinical features of COVID-19, current treatments, and scientific advances to combat the epidemic novel coronavirus were discussed
- ItemA Systematic review on childhood immunization among men with infants: Africa perspective(International Journal of Current Research in Medical Sciences, 2022) Emmanuel Ifeanyi ObeaguImmunization remains one of the cheapest and most cost effective means of protecting the masses from vaccine preventable diseases. Factors affecting Childhood immunization uptake at general practice level may be considered in terms of socio demographic variables, attitude and practice. This review was done to enlighten the public on Childhood Immunization in Africa. Different search engines were consulted to explore the literatures and ascertain the gaps in knowledge on Childhood Immunization in Africa. There has been increasing emphasis on preventive care, which has resulted in systematic differences in the success of practices for child immunization. Results indicate a high incidence of immunization practice among the households. Immunization for children is the effective, safe and efficient public health interventions to prevent childhood morbidity and mortality. This review found that most men have good knowledge, positive attitude with poor practice and involvement of immunization. There is a need to increase awareness about the benefits and importance of vaccination, as well as the harmful consequences of non-complete immunization.