The effect of extract of aloe vera on ischemia-reperfusion induced Mucosa injury in the rat
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Date
2014-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kampala international international: School of Health Sciences
Abstract
Aloe vera is one of the many herbal remedies used in Uganda for the treatment of a wide
range of illness ranging from trauma/ wounds to infections even for cosmetic purposes.
The research in to its protective role on ischemia induced gastric ulcers was aimed at
establishing and confirming its reported efficacy on peptic ulcers, time of onset of action
and time taken for an optimum therapeutic response. This research investigated the extent
of aloe vera's protective properties which were compared with the therapeutic effects of an
anti histamine ( ranitidine). The phytoextracts (mucilage) of the plant was administered to
the test subjects orally by a cunnula immediately prior to ulcer induction, thereafter the
subjects were sacrificed and stomach contents examined macroscopically by hand lens. The
histopathological data was collected appropriately compiled and computed using a
combination of textual, diagrammatic and graphical representations. This data showed
that aloe vera was effective in the prevention of peptic ulcers. Using a series of statistical
tools to ascertain the relevancy of the findings.
Description
A dissertation submitted to the school of pharmacy, Kampala international university in fulfillment of the award of degree Pharmacy
Keywords
Pharmacy, Ischemia-reperfusion, Aloe vera, Mucosa injury in the rat