Deciphering the Molecular Mechanisms Governing Autophagy: A Comprehensive Overview

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dc.contributor.authorNkiruka R Ukib
dc.contributor.authorMmesoma Jessica Nwankwo
dc.contributor.authorOnah C. E
dc.contributor.authorEzinne G. Ukibe
dc.contributor.authorBlessing C. Ukibe
dc.contributor.authorVictory Ezennia Ukibe
dc.contributor.authorEmmanuel Ifeanyi Obeagu
dc.date.accessioned2024-11-11T10:35:33Z
dc.date.available2024-11-11T10:35:33Z
dc.date.issued2024
dc.description.abstractAutophagy, an evolutionarily conserved cellular process, intricately regulates the degradation and recycling of cellular components, ensuring cellular homeostasis. The molecular orchestration of autophagy involves a sophisticated network of signaling pathways and key molecular players. Key initiation steps involve nutrient-sensing pathways, including mTOR and AMPK, converging on the ULK1 complex, triggering autophagosome formation. Subsequent stages encompass the role of the PI3K complex, recruitment of ATGs, and autophagosome expansion, leading to cargo recognition and closure. The selectivity in autophagy is achieved through cargo-specific adaptors and receptors like p62/SQSTM1, NIX/BNIP3L, and NDP52, ensuring targeted degradation of damaged organelles, misfolded proteins, and pathogens. Upon fusion with lysosomes, autolysosomes are formed, culminating in the breakdown of engulfed cargo via lysosomal hydrolases. Autophagy's intricate interplay with cellular processes, including metabolism, immunity, and cell death pathways, underscores its multifaceted roles in physiological and pathological conditions. Dysregulated autophagy is implicated in neurodegenerative disorders, cancer, metabolic diseases, and infections, highlighting its clinical relevance. Understanding the molecular mechanisms of autophagy offers promising prospects for therapeutic interventions by targeting autophagic pathways. This overview provides insights into the molecular intricacies of autophagy, offering potential avenues for therapeutic modulation in various disease contexts.
dc.description.sponsorshipKampala International University
dc.identifier.issn2736-7319
dc.identifier.urihttp://hdl.handle.net/20.500.12493/14576
dc.language.isoen
dc.publisherIAA Journal of Scientific Research
dc.titleDeciphering the Molecular Mechanisms Governing Autophagy: A Comprehensive Overview
dc.typeArticle
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Bachelor of Medical Laboratory Technology(BMLT)