New biologically active compounds from 1, 3-Diketones

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dc.contributor.authorMulongo, George
dc.contributor.authorMbabazi, Jolocam
dc.contributor.authorOdongkara, B
dc.contributor.authorTwinomuhwezi, H
dc.contributor.authorMpango, G.B
dc.date.accessioned2018-07-16T08:20:59Z
dc.date.available2018-07-16T08:20:59Z
dc.date.issued2011
dc.descriptionThe article is available full text. Dr. Mbabazi Jolocam is a lecturer at Kampala International University,en_US
dc.description.abstractThe ready availability of cyclohexanones and the enhanced reactivity at their -positions render them starting materials of choice in the present study. The synthesis of new compounds of antimicrobial activity was undertaken by the coupling of aromatic amines with 5,5-dimethyl cyclohexan-1,3-dione (dimedone). The products were refluxed with N–benzyl-N-phenylhydrazine in acetic acid. The structures of the products were elucidated using micro- and IR-spectral analyses. They were confirmed using 1H NMR at 60MHz and TMS as internal standard. The diketone derivatives were tested for their biological activity against gram-positive Cocci and Bacilli, and gram-negative Bacilli. The study showed that the derivatives gave a wide range of activity from inactive to highly active, which proves it to be of fresh pharmaceutical interest.en_US
dc.identifier.issn2031-606x
dc.identifier.urihttp://hdl.handle.net/20.500.12306/391
dc.language.isoenen_US
dc.publisherRes.J.Chem. Sc.en_US
dc.relation.ispartofseriesResearch Journal of Chemical Sciences;vol.1(3);
dc.subjectDimedoneen_US
dc.subjectAntimicrobial activityen_US
dc.subjectGram-positive Cocci and Bacillien_US
dc.subjectGram-negative Bacillien_US
dc.titleNew biologically active compounds from 1, 3-Diketonesen_US
dc.typeArticleen_US
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