Antimicrobial Resistance Patterns and Molecular Characterization of Klebsiella pneumoniae in Clinical Isolates at Mbarara Regional Referral Hospital

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dc.contributor.authorMusinguzi, Benson
dc.contributor.authorTurugurwa, Joseph
dc.contributor.authorMwesigye, James
dc.contributor.authorKassaza, Kennedy
dc.contributor.authorByarugaba, Fredrick
dc.contributor.authorKabanda, Taseera
dc.date.accessioned2019-10-03T10:30:02Z
dc.date.available2019-10-03T10:30:02Z
dc.date.issued2019
dc.descriptionJoseph Turugurwa1*, James Mwesigye1, Kennedy Kassaza1, Fredrick Byarugaba1, Taseera Kabanda1, Benson Musinguzi2* 1Department of Microbiology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda 2Department of Medical Laboratory Sciences, School of Allied Health Sciences, Kampala International University, Bushenyi, Ugandaen_US
dc.description.abstractBackground: Klebsiella pneumoniae is one of the most frequent opportunistic pathogens causing a range of infections and being resistant for beta-lactamases (ESBL) and Carbapenemases. Aim: The aim of the present study was to determine the antimicrobial resistance patterns and molecular characterization establishing the phenotypes and genotypes associated with drug resistance, an antibiogram of genotypically positive isolates for resistance of Klebsiella pneumoniae in clinical isolates at MRRH. Materials and Methods: A laboratory-based descriptive cross-sectional study that was conducted from September 2018 to May 2019 at MRRH. Klebsiella pneumoniae was identified by cultural and biochemical methods. Antibiotic sensitivity test was performed by modified Kirby-Bauer disc diffusion technique. ESBL production in Klebsiella pneumoniae was tested by double-disc synergy test, Carbapenemase production by MHT, Boronic Acid or EDTA test using Meropenem phenotypically and both resistance confirmed genotypically by Multiplex PCR. Results: Out of 1055 clinical isolates, 298 (28.2%) were found positiveen_US
dc.identifier.citationHow to cite this paper: Turugurwa, J., Mwesigye, J., Kassaza, K., Byarugaba, F., Kabanda, T. and Musinguzi, B. (2019) Antimicrobial Resistance Patterns and Molecular Characterization of Klebsiella pneumoniae in Clinical Isolates at Mbarara Regional Referral Hospital. Advances in Infectious Diseases, 9, 197-225. https://doi.org/10.4236/aid.2019.93015en_US
dc.identifier.issnISSN Online: 2164-2656
dc.identifier.issnISSN Print: 2164-2648
dc.identifier.urihttp://hdl.handle.net/20.500.12306/2099
dc.language.isoenen_US
dc.publisherScientific Research Publishingen_US
dc.subjectAntimicrobial Resistance Patternsen_US
dc.subjectMolecular Characterizationen_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectClinical Isolatesen_US
dc.subjectMbarara Regional Referral Hospitalen_US
dc.titleAntimicrobial Resistance Patterns and Molecular Characterization of Klebsiella pneumoniae in Clinical Isolates at Mbarara Regional Referral Hospitalen_US
dc.typeArticleen_US
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