Effects of lycopene on kidney antioxidant enzyme activities and functions in streptozotocin-induced diabetic Wistar rats

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dc.contributor.authorDaniel, EzeEjike
dc.contributor.authorMohammed, Aliyu
dc.contributor.authorTanko, Yusuf
dc.contributor.authorAhmed, Abubakar
dc.date.accessioned2019-02-15T12:30:13Z
dc.date.available2019-02-15T12:30:13Z
dc.date.issued2015
dc.descriptionThe article is available full texten_US
dc.description.abstractThe present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.en_US
dc.identifier.citationEze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed. Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biology. Vol. 3, No. 1, 2015, pp.1-13. doi: 10.11648/j.cb.20150301.11en_US
dc.identifier.issn2330-0183
dc.identifier.urihttp://hdl.handle.net/20.500.12306/1603
dc.language.isoenen_US
dc.publisherScientific Publishing Groupen_US
dc.relation.ispartofseriesCell Biology;Vol. 3, No. 1 pp.1-13.
dc.subjectDiabetes Mellitusen_US
dc.subjectLycopeneen_US
dc.subjectStreptozotocinen_US
dc.subjectElectrolytesen_US
dc.subjectAntioxidantsen_US
dc.subjectKidneyen_US
dc.subjectPathophysiological changesen_US
dc.titleEffects of lycopene on kidney antioxidant enzyme activities and functions in streptozotocin-induced diabetic Wistar ratsen_US
dc.typeArticleen_US
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