A systematic review: the current status of carbapenem resistance in East Africa

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dc.contributor.authorKenneth, Ssekatawa
dc.contributor.authorEdward, Wampande
dc.contributor.authorDennis, K. Byarugaba
dc.contributor.authorFrancis, Ejobi
dc.date.accessioned2024-02-27T14:57:19Z
dc.date.available2024-02-27T14:57:19Z
dc.date.issued2018
dc.description.abstractIn this systematic review, we present the molecular epidemiology and knowledge gaps of the carbapenem resistance in East Africa as well as the future probable research interventions that can be used to address the emergence of carbapenem resistance in the region. Results: The 17 articles which presented concrete information about the prevalence of carbapenem resistance in East Africa were reviewed. Tanzania exhibited the highest level of carbapenem resistance at 35% while DRC had the lowest level at 0.96%. Uganda was the only country with studies documenting CR obtained amongst hospital environment isolates with incidence ranging from 21% in Pseudomonas aeruginosa to 55% in Acinetobacter baumannii. Carbapenem resistance was more exhibited in A. baumannii (23%), followed by P. aeruginosa (17%), Klebsiella pneumoniae (15%), Proteus mirabilis (14%) and Escherichia coli (12%) mainly isolated from respiratory tract, blood, urine and wound/pus. The regional genetic determinants of carbapenem resistance detected were blaIMP, blaVIM-1 blaSPM-l, blaNDM-1, blaOXA-23 blaOXA-24, blaOXA-58 and blaKPC.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12306/14421
dc.language.isoenen_US
dc.publisherKampala International Universityen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectCarbapenem resistanceen_US
dc.subjectEast Africa,en_US
dc.titleA systematic review: the current status of carbapenem resistance in East Africaen_US
dc.typeArticleen_US
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