Diagnosis and Treatment of Immune Heamolytic Aneamia
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Newport International Journal of Biological and Applied Sciences (NIJBAS)
Abstract
Immune hemolytic anemia (IHA) stands as a multifaceted hematologic disorder characterized by accelerated destruction of red blood cells due to immune system dysregulation. This paper aims to elucidate the nuanced landscape of IHA, focusing on its diverse diagnostic approaches and evolving treatment strategies. Diagnostic considerations encompass a range of laboratory tests, including direct and indirect Coombs tests, hemolysis markers, and autoimmune antibody panels, elucidating their roles in confirming IHA etiology and subtype classification. Additionally, advancements in imaging modalities aid in identifying underlying causative factors contributing to hemolysis. The paper further scrutinizes therapeutic interventions, spanning corticosteroids, immunosuppressive agents, and monoclonal antibodies, while also appraising emerging modalities like rituximab and splenectomy. Moreover, the role of supportive care and transfusion strategies in managing IHAassociated complications is delineated. Challenges in IHA management, including refractory cases and adverse effects of therapies, are deliberated alongside the potential of future advancements in precision medicine and targeted therapies. By assimilating the latest diagnostic methodologies and treatment paradigms, this review provides a comprehensive outlook on navigating the complexities of immune hemolytic anemia to optimize patient care and outcomes.