Comparative evaluation of the disintegrant properties of starch derived from Musa Acuminata (Matooke Banana) and Zea Mays (Maize) in pediatric paracetamol tablets

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Kampala International University; School of Health Sciences
The aim of the study was to formulate paracetamol tablets using starch from Musa acuminate matooke banana as disintegrant in paracetamol tab lets. Paracetamol tablets were produced by wet granulation method using Musa acuminate starch as disintegrant in concentrations of 5%, 10%, and 15% w/w in comparison with official corn starch. The physiochemical and material properties of starches and granules were evaluated and the properties of paracetamol tablets prepared by wet granulation using starches as endo -disintegrant were determined. The necessary official and non-official I tests were performed on the tablets and that include uniformity of tablets weight Disintegration hardness, friability tests and dissolution. The results show that the granules had a fair no''' and values obtained were within the specified limits for the production of fairly good quality tablets. The percentage deviations obtained from the tablet weight uniformity test were below 7.5%. Tablets disintegration time test friability test and hardness test con formed to the specifications.. The dissolution test also showed that all the tablets in all the batches had a good drug release profile.
A research report submitted to the School of Pharmacy in partial fulfillment of the requirements for the Award of a Bachelor of Pharmacy Degree of Kampala International University
Comparative evaluation, Disintegrant properties of starch, Pediatric paracetamol tablets