Burden of Pediatric Typhoid Disease in Uganda: Causes, Consequences, and Prevention Strategies
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Date
2025
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Eurasian Experiment Journal of Public Health (EEJPH)
Abstract
Typhoid fever, caused by Salmonella enterica serovar Typhi, remains a critical public health challenge in Uganda, particularly affecting children in rural and peri-urban areas. Despite advances in healthcare, the disease continues to thrive due to factors such as inadequate water sanitation, poor hygiene practices, overcrowded living conditions, and limited access to healthcare services. Children under 15 bear the brunt of the disease, with a disproportionate incidence among school-aged children. The burden of pediatric typhoid fever includes significant morbidity, long term health consequences, and substantial economic strain on families. Typhoid fever is transmitted primarily through contaminated food and water, and the increasing prevalence of antibiotic-resistant Salmonella strains complicates treatment. This review examines the causes, risk factors, health consequences, and prevention strategies for pediatric typhoid fever in Uganda. Key interventions discussed include improved water, sanitation, and hygiene (WASH) programs, vaccination efforts, early diagnosis, and enhanced healthcare infrastructure. The review highlights the urgent need for comprehensive, multi-faceted approaches to reduce the burden of pediatric typhoid fever, with particular focus on expanding access to vaccines, strengthening healthcare systems, and addressing environmental determinants.