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- ItemImpact of Mobile Glucose Monitoring Versus Paper Logs on Self-Management Behavior in Adolescents with Type 1 Diabetes:(Research Output Journal of Engineering and Scientific Research, 2025) Kirenyo Nalubega F.Effective self-management of type 1 diabetes mellitus (T1DM) during adolescence is essential but challenging due to developmental, behavioral, and psychosocial complexities. This narrative review examined the impact of mobile glucose monitoring technologies compared to traditional paper logbooks on self-management behaviors in adolescents with T1DM. A comprehensive literature search was conducted through peer-reviewed studies published in the past decade, synthesizing evidence on adherence to glucose monitoring, insulin dosing, dietary regulation, psychosocial engagement, and communication with caregivers and healthcare providers. Findings indicated that mobile monitoring tools significantly improve the frequency and consistency of glucose checks, insulin adherence, and nutritional awareness by offering automated data logging, real-time feedback, and interactive interfaces. Adolescents report greater satisfaction and empowerment with digital tools, which are better aligned with their technological preferences and behavioral needs. Furthermore, mobile platforms enhance communication through remote data sharing, enabling timely clinical interventions and supportive parental oversight. However, limitations such as technological fatigue, data privacy concerns, and unequal access may hinder sustained use and equitable benefits. Despite these challenges, mobile monitoring represents a valuable adjunct to traditional care, promoting adolescent autonomy and engagement. Future research should explore long-term outcomes and strategies to optimize implementation across diverse populations.
- ItemImpact of Nurse-Led Home Visits on Foot Ulcer Prevention in Elderly Type 2 Diabetics:(Research Output Journal of Engineering and Scientific Research( ROJESR), 2025) Kirenyo Nalubega F.Foot ulcers are a prevalent and debilitating complication among elderly individuals with type 2 diabetes mellitus (T2DM), often resulting in increased morbidity, reduced mobility, and a heightened risk of lower limb amputation. As traditional outpatient models may fall short in addressing the preventive needs of this high-risk population, nurse-led home visits have emerged as a promising alternative. This review evaluated the impact of such interventions on foot ulcer prevention in elderly T2DM patients, synthesizing evidence from cluster randomized trials (CRTs). A narrative review methodology was employed, drawing insights from peer-reviewed CRTs that investigated clinical efficacy, behavioral outcomes, and implementation challenges associated with nurse-led home care models. Key components of these interventions include foot risk assessment, individualized education, self-care reinforcement, environmental hazard evaluation, and early referral for advanced care. Findings from CRTs consistently demonstrate a significant reduction in foot ulcer incidence and improvement in foot care practices among patients receiving home-based nursing care. Moreover, these interventions prove feasible and cost-effective, although challenges such as staffing limitations and reimbursement barriers persist. Nurse-led home visits not only enhance clinical outcomes but also align with broader goals of aging-in-place and chronic disease management. They represent a scalable and patient-centered strategy with substantial implications for geriatric diabetes care
- ItemGreen Nanotechnology in the Development of Antioxidant-Rich Phytotherapeutics for Metabolic Syndrome(Research Output Journal of Engineering and Scientific Research, 2025) Zikayo Amulaga R.Metabolic syndrome (MetS), a multifactorial disorder characterized by obesity, insulin resistance, hypertension, and dyslipidemia, has emerged as a global health challenge. Conventional therapeutic approaches often come with side effects and limited long-term efficacy. Phytotherapeutics, derived from medicinal plants and rich in natural antioxidants, offer a promising alternative for managing MetS. However, issues such as poor bioavailability, instability, and low solubility limit their clinical applicability. Green nanotechnology—a sustainable approach to nanomaterial synthesis using biological resources—offers a breakthrough in enhancing the delivery and efficacy of phytochemicals. This review provides an overview of the pathophysiology of metabolic syndrome and the limitations of traditional therapies. It further explores the integration of green nanotechnology in designing nanoformulations of antioxidant-rich phytotherapeutics. Special attention is given to the mechanisms, recent advancements, types of green nanoparticles, and their synergistic potential in managing oxidative stress and metabolic dysfunction. The article also discusses safety, regulatory challenges, and prospects of green nano-based phytotherapeutics in combating metabolic syndrome.
- ItemExploring the Role of Oxidative Stress in the Pathophysiology of Metabolic Syndrome: Implications for Therapeutic Targeting(Research Invention Journal of Research in Medical Sciences, 2025) Mugisha Byaruhanga P.Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including central obesity, insulin resistance, hypertension, dyslipidemia, and pro-inflammatory states, which significantly increase the risk of cardiovascular diseases, type 2 diabetes, and other complications. Emerging evidence suggests that oxidative stress plays a critical role in the pathophysiology of MetS by exacerbating inflammation, impairing insulin signaling, and promoting cellular dysfunction. Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses, contributes to the development and progression of metabolic abnormalities that characterize MetS. This review examines the role of oxidative stress in MetS, focusing on its impact on insulin resistance, endothelial dysfunction, adiposity, and inflammatory responses. Additionally, it explores potential therapeutic approaches aimed at modulating oxidative stress, including the use of antioxidants, lifestyle interventions, and pharmacological agents. Although antioxidant therapies have shown promise, challenges such as the safe and effective use of antioxidants in clinical settings, as well as the complex interactions between oxidative stress and other pathophysiological processes, remain. This article provides a comprehensive overview of the role of oxidative stress in MetS and highlights potential therapeutic strategies to mitigate its effects, offering insights into future research directions in this area.
- ItemEffect of Mobile Health Reminders on Antimalarial Adherence among Pregnant Women in Rural Uganda: A Randomized Controlled Trial(Research Output Journal f Engineering and Scientific Research, 2025) Kagambira Zimbuga M.Malaria in pregnancy remains a critical public health issue in sub-Saharan Africa, particularly in Uganda, where adherence to intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is persistently low. Poor adherence contributes to adverse maternal and neonatal outcomes, necessitating innovative solutions to enhance antimalarial prophylaxis. Mobile health (mHealth) interventions, such as SMS and voice call reminders, have emerged as promising tools to support treatment adherence in low-resource settings. This review evaluated the effect of mobile health reminders on antimalarial adherence among pregnant women in rural Uganda, drawing evidence from a randomized controlled trial involving 600 participants. The trial compared standard antenatal care with an intervention group receiving scheduled mobile reminders before each IPTp-SP dose. Findings revealed a significant improvement in adherence, with 72% of women in the intervention group completing three or more IPTp-SP doses versus 49% in the control group. Improved antenatal attendance, higher maternal hemoglobin levels at delivery, and high user satisfaction were also observed. The article was developed using a structured literature synthesis method focused on trial-based findings and contextual analysis. Despite challenges related to phone access, network coverage, and message delivery, the intervention demonstrated feasibility, scalability, and acceptability. This review underscored the potential of mHealth to enhance malaria prevention efforts in maternal healthcare programs.