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- ItemUpdate on mothers towards neonatal umbilical cord sepsis: African perspectives(International Journal of Current Research in Medical Sciences, 2023) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Esther Musiimenta; Yakubu Sunday Bot1; Abdulwasiu Oladele HassanNeonatal umbilical sepsis continues to be a major health problem with up to 323 of every 1000 neonates seen clinics presenting with clinical symptoms. The unhealed umbilical cord is a major entry point for local and invasive infections during the neonatal period and is rapidly colonised by bacteria from the environment. The reasons for the high incidence of neonatal sepsis in developing countries are high incidence of home deliveries, unhygienic cord utting, application of unclean substances to the stump and covering the stump with unclean fabric
- ItemHematologic Support in HIV Patients: Blood Transfusion Strategies and Immunological Considerations(Newport International Journal of Biological and Applied Sciences (NIJBAS), 2023) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Joseph Obiezu; Chukwujekwu Ezeonwumelu; Frances Ugonne Ogunnaya; Anthonia Onyinye Ngwoke; Obioma Raluchukwu Emeka-Obi; Okechukwu Paul-Chima UgwuHIV infection presents multifaceted challenges, particularly in managing hematologic complications that significantly impact patient well-being and prognosis. Hematologic manifestations such as anemia, thrombocytopenia, and coagulopathies are prevalent in individuals living with HIV, necessitating meticulous attention and specialized care. Among the array of interventions, blood transfusions play a pivotal role in addressing these hematologic complications. However, the complexities surrounding blood transfusion strategies in the context of HIV extend beyond mere hematologic support and delve into intricate immunological considerations. This paper aims to elucidate the nuanced landscape of hematologic support in HIV patients, focusing specifically on blood transfusion strategies and their immunological implications. The review encompasses an in-depth analysis of hematologic abnormalities commonly encountered in HIV, exploring the prevalence, etiology, and clinical impact of anemia, thrombocytopenia, and coagulopathies. Additionally, it examines the indications, safety measures, and challenges associated with blood transfusion therapy in this population. Furthermore, the paper delineates the intricate interplay between blood transfusions and the immunological milieu of HIV-infected individuals. It explores the immunomodulatory effects of transfusions, potential immune activation, and the impact on disease progression, while also addressing concerns regarding all immunization and the modulation of immune responses post transfusion. By synthesizing current evidence and insights, this paper delineates the clinical outcomes, challenges, and controversies surrounding blood transfusion strategies in HIV care. It underscores the need for optimized transfusion practices tailored to the unique immunological landscape of HIV patients and highlights avenues for future research and advancements in clinical practice. In conclusion, this paper serves as a comprehensive resource elucidating hematologic support through blood transfusion strategies in HIV patients, providing a foundation for informed decision-making and paving the way for enhanced care paradigms in the management of hematologic complications in HIV.
- ItemHematocrit Variations in HIV Patients Co-infected with Malaria: A Comprehensive Review(International Journal of Innovative and Applied Research, 2024) Emmanuel Ifeanyi Obeagu; Getrude Uzoma ObeaguCo-infection with both HIV and malaria presents a complex medical challenge, particularly concerning hematocrit variations that often result in anemia in affected individuals. This comprehensive review aims to explore and synthesize existing literature to elucidate the multifaceted nature of hematocrit alterations observed in HIV patients concurrently infected with malaria. The pathophysiological mechanisms contributing to hematocrit variations in this co-infected population involve a complex interplay between the immunosuppressive effects of HIV and the hemolytic nature of malaria parasites. Understanding these mechanisms is crucial for developing targeted interventions. Diagnostic challenges abound due to overlapping symptoms and limitations in conventional diagnostic tools, necessitating the exploration of more advanced diagnostic methodologies to accurately assess and monitor hematocrit levels in co-infected individuals. The clinical implications of hematocrit variations in this context extend beyond mere anemia, impacting disease severity, treatment response, and the overall prognosis of affected patients. Anemia complicates therapeutic
- ItemHematocrit Fluctuations in HIV Patients Co infected with Malaria Parasites: A Comprehensive Review(International Journal of Current Research in Medical Sciences, 2024) Emmanuel Ifeanyi Obeagu; Getrude Uzoma ObeaguThe co-occurrence of HIV and malaria co-infection presents a considerable health challenge, particularly in regions where both diseases are endemic. Hematocrit, a vital marker reflecting the proportion of red blood cells in circulation, plays a crucial role in understanding the impact of these co-infections on overall health. This comprehensive review examines the intricate relationship between hematocrit fluctuations and the concurrent presence of HIV and malaria parasites, addressing keywords such as anemia, immune response, antiretroviral therapy, and immunomodulation. The review synthesizes existing knowledge, exploring the individual influences of HIV and malaria on hematocrit levels, and delving into the synergistic effects observed in co-infected individuals. Clinical implications, including diagnostic challenges and treatment strategies, are discussed, emphasizing the need for a multidisciplinary approach. Additionally, the review identifies research gaps and proposes future directions, highlighting the importance of longitudinal studies to elucidate the long-term impact of co-infection on hematocrit dynamics. Overall, this review provides a comprehensive understanding of hematocrit fluctuations in the context of HIV-malaria co-infection, aiming to guide clinicians and researchers in developing effective management strategies for this complex and vulnerable population
- ItemGender-based evaluation of haematological and some inflammation markers in patients with mandibular fracture in a tertiary Hospital in southeast, Nigeria(Academic Journal of Health Sciences, 2023) Emmanuel Ifeanyi Obeagu; Pilar Tomás-Gil; Josep Lluis Coll Villalonga; Pau Martí-Lliteras; Getrude Uzoma ObeaguAim: The study was done to evaluate hematological parameters and some inflammatory markers in patients with mandibular fractures in a tertiary hospital in Southeast, Nigeria. Methods: A total of 100 subjects were selected for the study comprising of 50 patients with mandibular fracture and 50 apparently healthy individuals attended National Orthopedic Hospital, Enugu, Nigeria. About 3ml of venous blood was collected from antecubital fossa following aseptic techniques into EDTA containers for FBC determinations. The full blood counts of the subjects were determined using MIndray BC-3000 Plus. The data were analyzed using student t-test and present as mean ± standard deviation using SPSS version 20 and level of significance set at P<0.05. Results: The study showed increase in the red lines such as the red cells, hemoglobin and Packed Cell Volume of the male compared to the females. Conclusions: The society are advised to minimize some activities that will predispose them to mandibular factures as there are limited surgeons with expertise in this part of the world to resolve the issues fast and with utmost well-being of the patients.