Bachelor of Medicine and Surgery (BMS)

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https://testir.kiu.ac.ug/handle/20.500.12306/3770

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Browsing Bachelor of Medicine and Surgery (BMS) by Author "Emmanuel Ifeanyi Obeagu"

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    An Insight of Interleukin -6 and Fibrinogen: In Regulating the Immune System
    (Journal of Biomedical Sciences, 2022) Emmanuel Ifeanyi Obeagu; Emmanuel Muhimbura; Byamungu Pahari Kagenderezo; Sarah Nakyeyune; Getrude Uzoma Obeagu
    The role of the liver as a critical part of the immune system involved in both innate and adaptive immunity. As a major source of acute phase proteins, including components of the complement system. Hepatocytes are an important part of innate immunity and play an important role in controlling inflammatory responses throughout the body. Acute-phase protein production in hepatocytes is controlled by various cytokines released during the inflammatory process, with IL-6 and IL-1 type cytokines acting as key regulators, cascading and synergistic regulation or it functions as a cascade network with inhibition. Effects on acute-phase protein expression. The pro inflammatory cytokine interleukin-6 is an endogenous biochemical active during B cell maturation and inflammatory processes. Interleukin-6 plays an important role in regulating acute-phase protein synthesis in human hepatocytes.
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    Codeine Substitute Challenges Drug and Substance Abuse Controls in Nigeria: Histopathology Evaluations of Norvegicus rattus on Lacatomtom
    (Journal of Complementary and Alternative Medical Research, 2022) Nnaemeka Okorie; Emmanuel Ifeanyi Obeagu; Olayinka Catherine Adeniran; Azi Simon Onyema; Ude, Ugomma Agwu
    Codeine substitute challenges to drug and substance abuse controls in Nigeria: Histopathology evaluations of Norvegicus rattus on lacatomtom is novel research that aimed to evaluate the Codeine substitute challenges to drugs and substance abuse; histopathology perspective and oxidative biomarkers evaluation of the tissues cum chemical pathology analysis of the serum of the control and intervened subjects. The experimental subjects were grouped into control, acute and chronic (T1, T2, and T3) respectively; the acute groups of the oral administration of lacatomtom mixture were given 0.01mg/g of lacatomtom for 14 days while the chronic were given for 42 days and periodically weighed and recorded; The Animals were sacrificed and the organs harvested following ethical procedures for animal killing. The blood and tissues of the harvested organs (blood, lungs, liver, and kidney) under investigation were subjected to chemical pathology analysis to assess the liver and kidney functions, then proceeded to histopathological examination using formalin fixed paraffin processed methods with both routine and special stains, liver, lungs and kidney homogenate were subjected to oxidative stress biomarkers test (MDA, SOD, Gpx, GSH and Catalase). Histopathology results first revealed a severe cellular injury in all the organs under study compare to the normal control; significance (p<0.5) elevation found among some enzymes AST, ALP ALT are also an indication of damaged liver, increase MDA and reduced SOD, Gpx, GSH and catalase correlate the histology results and biochemistry.