(Journal of Biomedical Sciences, 2022) Emmanuel Ifeanyi Obeagu; Emmanuel Muhimbura; Byamungu Pahari Kagenderezo; Sarah Nakyeyune; Getrude Uzoma Obeagu
The role of the liver as a critical part of the immune system involved in both innate and adaptive immunity. As a major source of acute phase proteins, including components of the complement system. Hepatocytes are an important part of innate immunity and play an important role in controlling inflammatory responses throughout the body. Acute-phase protein production in hepatocytes is controlled by various cytokines released during the inflammatory process, with IL-6 and IL-1 type cytokines acting as key regulators, cascading and synergistic regulation or it functions as a cascade network with inhibition. Effects on acute-phase protein expression. The pro inflammatory cytokine interleukin-6 is an endogenous biochemical active during B cell maturation and inflammatory processes. Interleukin-6 plays an important role in regulating acute-phase protein synthesis in human hepatocytes.