Browse
Recent Submissions
Now showing 1 - 5 of 19
- ItemAnemia, iron, and HIV: decoding the interconnected pathways A review(Medicine, 2024) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Nkiruka Rose Ukibe; Samson Adewale OyebadejoThis review delves into the intricate relationship between anemia, iron metabolism, and human immunodeficiency virus (HIV), aiming to unravel the interconnected pathways that contribute to the complex interplay between these 3 entities. A systematic exploration of relevant literature was conducted, encompassing studies examining the association between anemia, iron status, and HIV infection. Both clinical and preclinical investigations were analyzed to elucidate the underlying mechanisms linking these components. Chronic inflammation, a hallmark of HIV infection, disrupts iron homeostasis, impacting erythropoiesis and contributing to anemia. Direct viral effects on bone marrow function further compound red blood cell deficiencies. Antiretroviral therapy, while essential for managing HIV, introduces potential complications, including medication-induced anemia. Dysregulation of iron levels in different tissues adds complexity to the intricate network of interactions. Effective management of anemia in HIV necessitates a multifaceted approach. Optimization of antiretroviral therapy, treatment of opportunistic infections, and targeted nutritional interventions, including iron supplementation, are integral components. However, challenges persist in understanding the specific molecular mechanisms governing these interconnected pathways. Decoding the interconnected pathways of anemia, iron metabolism, and HIV is imperative for enhancing the holistic care of individuals with HIV/AIDS. A nuanced understanding of these relationships will inform the development of more precise interventions, optimizing the management of anemia in this population. Future research endeavors should focus on elucidating the intricate molecular mechanisms, paving the way for innovative therapeutic strategies in the context of HIV-associated anemia.
- ItemAdvancements in Myeloid Leukemia Treatment:A Comprehensive Update.(Journal of Biological Sciences, 2023) Hauwa Ali Buhari; Salisu, Muhammad; Obeagu Emmanuel IfeanyiThis comprehensive update explores the recent advancements in the treatment landscape of myeloid leukemia. Myeloid leukemia, a heterogeneous group of hematological malignancies, poses significant challenges in clinical management. This review highlights the latest therapeutic approaches, including targeted therapies, immunotherapies, and emerging treatment modalities. It discusses the impact of precision medicine, novel drug developments, and the evolving role of immunotherapy in managing myeloid leukemia. Furthermore, the abstract outlines current research trends, challenges, and future prospects, aiming to provide a concise overview for healthcare professionals and researchers involved in leukemia management.
- ItemAdvancements in Immune Augmentation Strategies for HIV Patients(IAA Journal of Biological Sciences, 2023) Emmanuel Ifeanyi Obeagu; Getrude Uzoma Obeagu; Esther Ugo Alum; Okechukwu Paul-Chima UgwuThe management of HIV has witnessed a transformative shift owing to innovative approaches aimed at bolstering immune status in affected individuals. The landscape of HIV treatment has undergone a profound transformation with the emergence of innovative approaches dedicated to fortifying the immune status of individuals living with the virus. This abstract provides a succinct yet comprehensive overview of groundbreaking strategies aimed at augmenting immune health in HIV patients. Encompassing advancements in immunotherapy, personalized medicine, lifestyle modifications, and telemedicine, this overview highlights the promising trajectory and potential impact of these novel interventions in the realm of HIV care. By exploring the multifaceted dimensions of immune enhancement strategies, this abstract sets the stage for a deeper understanding of these innovative approaches and their pivotal role in shaping the future of HIV management
- ItemBenign Prostatic Hyperplasia :A Review(Eurasian Experiment Journal of Public Health, 2023) Emmanuel Ifeanyi Obeagu; U. Alum Esther; Getrude Uzoma Obeagu; Okechukwu Paul-Chima UgwuBenign Prostatic Hyperplasia (BPH) is a noncancerous increase in size of the prostate gland. The symptoms of BPH are mostly lower urinary tract symptoms and these include waking up to urinate at night, urgency, frequency, incontinence of urine and inability to empty the bladder completely and weak urine stream. Nocturia in particular has been found to have negative effect on quality of sleep, energy or vitality. Men realizes they have prostate enlargement when they start experiencing lower urinary tract symptoms. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment.
- ItemDevelopment of Atherosclerosis in Adulthood: Mini Review(International Digital Organization for Scientific Research :, 2024) Mathias Abiodun Emokpae; Timothy God-Giveth Olusegun; Oluwasina Moses Egbeyemi; Emmanuel Ifeanyi ObeaguThe lipid profile during the neonatal period plays a pivotal role in determining the future risk of atherosclerosis and cardiovascular diseases in adulthood. Abnormal lipid levels in neonates have been associated with an increased Propensity for the development of atherosclerosis later in life. This review aims to explore the significance of Abno mal lipid profiles in neonates and their potential implications for the development of atherosclerosis in adulthood. The discussion encompasses the mechanisms underlying lipid metabolism in early life, the impact of various factors on lipid levels in neonates, and the long-term consequences of abnormal lipid profiles. Understanding relationship between neonatal lipid profiles and the risk of atherosclerosis in adulthood is crucial for developing preventive strategies and interventions aimed at reducing the burden of cardiovascular diseases in later life. This review synthesizes idea from existing literature to provide insights into the importance of early lipid assessment and its implications for long-term cardiovascular health.