Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides

Ondieki, Miruka Conrad; Nyaribari, Matunda Conradus; Ejekwumadu, Nnamdi John; Nyakang’o, Mokembo Justin

Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides

Files

Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I.pdf(786.35 KB)

Date

2015-02

Authors

Ondieki, Miruka Conrad

Nyaribari, Matunda Conradus

Ejekwumadu, Nnamdi John

Nyakang’o, Mokembo Justin

Publisher

OMICS Publishing Group

Abstract

The hepatitis B virus continues to infect many millions of people worldwide. There is a need to develop new vaccines against the virus. Using immunoinformatics approaches, we have predicted epitopes within the hepatitis B virus surface antigen that can be used to develop a new vaccine. The predicted epitopes were then used to construct a synthetic vaccine. The interaction between the synthetic vaccine construct and major histocompatibility complex was also predicted using bioinformatics tools.

Description

The article is available full text.

Keywords

Hepatitis B, Vaccine, In silico, Immune informatics, HLA-I Peptides, Homology

Citation

Miruka CO, Matunda NC, Ejekwumadu NJ, Mokembo JN (2015) Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides. J Biomol Res Ther 4: 120. doi: 10.4172/2167-7956.1000120

URI

http://hdl.handle.net/20.500.12306/1596

Collections

Department of Biochemistry

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