Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides
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Date
2015-02
Journal Title
Journal ISSN
Volume Title
Publisher
OMICS Publishing Group
Abstract
The hepatitis B virus continues to infect many millions of people worldwide. There is a need to develop new
vaccines against the virus. Using immunoinformatics approaches, we have predicted epitopes within the hepatitis B
virus surface antigen that can be used to develop a new vaccine. The predicted epitopes were then used to construct
a synthetic vaccine. The interaction between the synthetic vaccine construct and major histocompatibility complex
was also predicted using bioinformatics tools.
Description
The article is available full text.
Keywords
Hepatitis B, Vaccine, In silico, Immune informatics, HLA-I Peptides, Homology
Citation
Miruka CO, Matunda NC, Ejekwumadu NJ, Mokembo JN (2015) Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides. J Biomol Res Ther 4: 120. doi: 10.4172/2167-7956.1000120