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http://hdl.handle.net/20.500.12306/1596| Title: | Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides |
| Authors: | Ondieki, Miruka Conrad Nyaribari, Matunda Conradus Ejekwumadu, Nnamdi John Nyakang’o, Mokembo Justin |
| Keywords: | Hepatitis B Vaccine In silico Immune informatics HLA-I Peptides Homology |
| Issue Date: | Feb-2015 |
| Publisher: | OMICS Publishing Group |
| Citation: | Miruka CO, Matunda NC, Ejekwumadu NJ, Mokembo JN (2015) Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I Peptides. J Biomol Res Ther 4: 120. doi: 10.4172/2167-7956.1000120 |
| Series/Report no.: | Biomolecular Research & Therapeutics;Ther 4: 120 |
| Abstract: | The hepatitis B virus continues to infect many millions of people worldwide. There is a need to develop new vaccines against the virus. Using immunoinformatics approaches, we have predicted epitopes within the hepatitis B virus surface antigen that can be used to develop a new vaccine. The predicted epitopes were then used to construct a synthetic vaccine. The interaction between the synthetic vaccine construct and major histocompatibility complex was also predicted using bioinformatics tools. |
| Description: | The article is available full text. |
| URI: | http://hdl.handle.net/20.500.12306/1596 |
| Appears in Collections: | Department of Biochemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Design of a Recombinant Hepatitis B Vaccine Based on Stably Binding HLA-I.pdf | 786.35 kB | Adobe PDF |  View/Open |
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