Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12306/1603
Title: Effects of lycopene on kidney antioxidant enzyme activities and functions in streptozotocin-induced diabetic Wistar rats
Authors: Daniel, EzeEjike
Mohammed, Aliyu
Tanko, Yusuf
Ahmed, Abubakar
Keywords: Diabetes Mellitus
Lycopene
Streptozotocin
Electrolytes
Antioxidants
Kidney
Pathophysiological changes
Issue Date: 2015
Publisher: Scientific Publishing Group
Citation: Eze Ejike Daniel, Aliyu Mohammed, Yusuf Tanko, Abubakar Ahmed. Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity and Functions in Streptozotocin-Induced Diabetic Wistar Rats. Cell Biology. Vol. 3, No. 1, 2015, pp.1-13. doi: 10.11648/j.cb.20150301.11
Series/Report no.: Cell Biology;Vol. 3, No. 1 pp.1-13.
Abstract: The present study assessed the effects of lycopene on kidney antioxidant enzymes activities and functions in streptozotocin-induced diabetic Wistar rats.Diabetes was induced in animals by single intra-peritoneal injection of streptozotocin. Thereafter the animals were randomly assigned into the following groups: Group I and II (Normal control + olive oil and Diabetic control + olive oil)while Group III to VI were treated with (10, 20 and 40 mg/kg of lycopene and 2 mg/kg glibenclamide) respectively. Alltreatments were givenonce daily orally for four weeks. Results obtained showed that blood glucose was significantly (P < 0.05) reduced. MDAconcentration was reduced in kidney tissue, with increased activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) in diabetic animals administered with lycopene when compared with diabetic control group.There was significant (P < 0.05) increase in the level of serum sodium ion and reduction in serum urea level in diabetic rats treated with lycopene when compared with the diabetic control group. Histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosisin all treated groups when compared with control group. It can be concluded that lycopene protects against diabetes-induced kidney damage through elevation of endogenous antioxidant enzymes and improved renal dysfunction in diabetic animals.
Description: The article is available full text
URI: http://hdl.handle.net/20.500.12306/1603
ISSN: 2330-0183
Appears in Collections:Department of Physiology

Files in This Item:
File Description SizeFormat 
Effect of Lycopene on Altered Kidney Antioxidant Enzymes Activity.pdf1.91 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.